A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation
A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation
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DOI：
10.1126/science.1057586
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发表时间：
2001-03-16
期刊：
影响因子：
56.9
通讯作者：
Greenstein, D
中科院分区：
文献类型：
--
作者：
Miller, MA;Nguyen, VQ;Greenstein, D
与大多数动物一样，秀丽隐杆线虫的卵母细胞在减数分裂前期停滞，精子促进减数分裂的恢复（成熟）和平滑肌样性腺鞘细胞的收缩，这是排卵所必需的，我们发现主要的精子细胞骨架蛋白（MSP）是卵母细胞成熟和鞘收缩的两部分信号。MSP也在精子运动中发挥类似于肌动蛋白的作用，因此，在进化过程中，MSP获得了细胞外信号和细胞内细胞骨架的生殖功能。具有msp样结构域的蛋白质存在于植物、真菌和其他动物中，表明相关的信号功能可能存在于其他门中。
Caenorhabditis elegans oocytes, Like those of most animals, arrest during meiotic prophase, Sperm promote the resumption of meiosis (maturation) and contraction of smooth muscle-like gonadal sheath cells, which are required for ovulation, We show that the major sperm cytoskeletal protein (MSP) is a bipartite signal for oocyte maturation and sheath contraction. MSP also functions in sperm Locomotion, playing a role analogous to actin, Thus, during evolution, MSP has acquired extracellular signaling and intracellular cytoskeletal functions for reproduction. Proteins with MSP-like domains are found in plants, fungi, and other animals, suggesting that related signaling functions may exist in other phyla.