The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography
The repeatability of superficial retinal vessel density measurements in eyes with long axial length using optical coherence tomography angiography
复制标题
使用光学相干断层扫描血管造影测量长眼轴浅层视网膜血管密度的可重复性
DOI：
10.1186/s12886-018-0992-y
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发表时间：
2018-12-17
影响因子：
2
通讯作者：
Qu, Jinfeng
中科院分区：
文献类型：
--
作者：
Li, Mengyang;Jin, Enzhong;Qu, Jinfeng
研究光学相干断层扫描血管造影（OCTA）在长轴长（AL）健康眼中测量视网膜浅血管密度的可重复性。方法对31名志愿者的60只眼睛进行横断面观察研究。所有受试者均行OCTA、AL和屈光测试。将入组眼分为长AL组（26 mm≤AL < 28 mm）和正常AL组（22 mm≤AL < 26 mm）。评估视网膜浅血管的血管长度密度（VLD）、灌注密度（PD）和中央凹无血管带（FAZ）。通过类内相关系数（ICCs）和Bland-Altman分析评估重复性。采用Pearson’s r相关分析AL与两个测量值的绝对差的关系。结果3 × 3 mm扫描图重复性好，ICCs均大于0.7。在所有扫描模式的各项参数中，正常AL组的icc明显高于长AL组；Bland-Altman分析也证实了这一发现。AL与OCTA参数重复性的相关分析显示，AL与6 × 6 mm内环VLD重复性（r2= 0.13,p= 0.01）、6 × 6 mm外环VLD （r2= 0.09,p= 0.02）、6 × 6 mm外环PD （r2= 0.08,p= 0.03）呈显著负相关。结论在OCTA中，AL和扫描面积都会影响视网膜浅血管密度测量的重复性。
BackgroundTo investigate the repeatability of superficial retinal vessel density measurements in healthy eyes with long axial length (AL) using optical coherence tomography angiography (OCTA).MethodsThere were 60 eyes of 31 volunteers enrolled in this cross-sectional observational study. All subjects underwent OCTA, AL and refraction test. The enrolled eyes were divided into the long AL group (26 mm ≤ AL < 28 mm) and normal AL group (22 mm ≤ AL < 26 mm). The vessel length density (VLD), perfusion density (PD), and fovea avascular zone (FAZ) of the superficial retinal vessel were evaluated. Repeatability was assessed by intraclass correlation coefficients (ICCs) and Bland-Altman analysis. Pearson’s r correlation was used to analyze the relation of AL and the absolute difference between two measurements.ResultsThe 3 × 3 mm scan pattern showed good repeatability with all ICCs over 0.7. For all parameters of all scan patterns, the ICCs of the normal AL group were distinctly higher than those of the long AL group; this finding was also confirmed by Bland-Altman analysis. The correlation analysis of AL and repeatability of OCTA parameters showed significant negative correlations between the ALs and repeatability of VLD in 6 × 6 mm inner ring (r2= 0.13,p= 0.01), VLD in 6 × 6 mm outer ring (r2= 0.09,p= 0.02) and PD in 6 × 6 mm outer ring (r2= 0.08,p= 0.03).ConclusionsThe AL and the scanned area will both affect the repeatability of superficial retinal vessel density measurements in OCTA.