Stimulation of carotid chemoreceptors and ventilation by doxapram in the cat.
Stimulation of carotid chemoreceptors and ventilation by doxapram in the cat.
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多沙普仑对猫颈动脉化学感受器和通气的刺激。
DOI：
10.1152/jappl.1982.52.5.1261
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Lahiri,S
中科院分区：
文献类型：
--
作者：
Nishino,T;Mokashi,A;Lahiri,S
使用小剂量多沙普仑（静脉注射少于 0.5 mg·kg-1）来研究其对用 α-氯醛糖麻醉的猫的颈动脉化学感受器活性和通气的影响。在动脉血中 O2 和 CO2 分压（PaO2 和 PaCO2）的几个水平上研究了这种影响。结果发现，在所研究的所有 PaO2 和 PaCO2 水平上，多沙普仑以相同的幅度刺激颈动脉化学感受器传入神经的放电速率。然而，多沙普仑的通气作用不仅仅是对缺氧或高碳酸血症的伴随刺激的附加作用。通过切开颈动脉窦和主动脉神经来消除这种通气效应。这些结果得出这样的结论：多沙普仑引起的通气刺激相互作用依赖于外周化学感受器的兴奋性输入。
Small doses of doxapram (less than 0.5 mg . kg-1 iv) were used to study its effect on carotid chemoreceptor activity and ventilation in cats anesthesized with alpha-chloralose. The effects were studied at several levels of partial pressures of O2 and CO2 in arterial blood (PaO2 and PaCO2). It was found that doxapram stimulated discharge rate of the carotid chemoreceptor afferents by the same magnitude at all levels of PaO2 and PaCO2 studied. However, the ventilatory effect of doxapram was more than additive to the concomitant stimulation by hypoxia or hypercapnia. This ventilatory effect was eliminated by sectioning the carotid sinus and aortic nerves. These results led to the conclusion that the ventilatory stimulus interaction due to doxapram is dependent on the excitatory input from the peripheral chemoreceptors.