The IKK complex:: an integrator of all signals that activate NF-κB?
The IKK complex:: an integrator of all signals that activate NF-κB?
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DOI：
10.1016/s0962-8924(00)01729-3
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发表时间：
2000-04-01
影响因子：
19
通讯作者：
Israël, A
中科院分区：
文献类型：
--
作者：
Israël, A
nf - κ B家族转录因子在免疫、炎症和凋亡反应中起着至关重要的作用。这些蛋白通常存在于细胞质中，通过与一种叫做I κ B的抑制分子相互作用而保留。nf - κ B信号级联的激活导致I κ B的磷酸化和降解，从而允许nf - κ B复合物的核易位。最近发现了一种含有两个激酶和一个调节亚基的高分子量复合物，这导致了一系列新的结果，揭示了一些最复杂的机制，这些机制有助于对nf - κ B活性的精确调节。
The NF-kappa B family of transcription factors plays a crucial role in the immune, inflammatory and apoptotic responses. These proteins are normally found in the cytoplasm, retained by interaction with an inhibitory molecule called I kappa B. Activation of the NF-kappa B signalling cascade results in phosphorylation and degradation of I kappa B, allowing nuclear translocation of the NF-kappa B complexes. The recent identification of a high-molecular-weight complex containing two kinases and a regulatory subunit has led to a flurry of new results that shed light on some of the most complex mechanisms contributing to the exquisite regulation of NF-kappa B activity.