Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects
Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects
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DOI：
10.1097/01.hjh.0000358834.18311.fc
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发表时间：
2009-08-01
影响因子：
4.9
通讯作者：
Arribas, Silvia M.
中科院分区：
文献类型：
--
作者：
Bernatova, Iveta;Victoria Conde, M.;Arribas, Silvia M.
自发性高血压大鼠（SHR）是一种常用的实验性高血压模型，尽管对SHR的导管和阻力动脉存在内皮功能障碍已达成共识，但仍有许多报道显示SHR的内皮依赖性血管舒张反应与正常血压大鼠相似，甚至增强。本文旨在讨论这些明显差异的基本原理，包括年龄、动脉类型和方法学方面的影响。来自文献的数据表明，动物的年龄是一个影响因素，内皮功能障碍可能是高血压的后果。此外，使用抗氧化剂添加剂，如抗坏血酸或乙二胺四乙酸，以及初始动脉拉伸水平的差异也可能很重要，因为它们可以改变动脉的氧化状态和内皮释放的血管活性因子的水平。J Hypertens 27（增刊6）：S27-S31（C）2009年威科健康垂直酒吧Lippincott威廉姆斯&威尔金斯。
Despite the apparent consensus on the existence of endothelial dysfunction in conduit and resistance arteries of spontaneously hypertensive rats (SHR), a commonly employed experimental model of hypertension, there are a number of reports showing that endothelium-dependent vasodilatory responses are similar, or even increased, in SHR compared with their normotensive counterparts. The present paper aims to discuss the rationale for these apparent discrepancies, including the effect of age, type of artery and methodological aspects. Data from the literature indicate that the age of the animal is a contributing factor and that endothelial dysfunction is likely to be a consequence of hypertension. In addition, the use of antioxidant additives, such as ascorbic acid or ethylene diaminetetraacetic acid, and differences in the level of initial arterial stretch, might also be of importance because they may modify the oxidative status of the artery and the levels of vasoactive factors released by the endothelium. J Hypertens 27 (suppl 6):S27-S31 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.