Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography.
Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography.
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DOI：
10.3164/jcbn.17-41
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发表时间：
2017-09
影响因子：
2.4
通讯作者：
Iwakiri K
中科院分区：
文献类型：
--
作者：
Hashimoto S;Futagami S;Yamawaki H;Kaneko K;Kodaka Y;Wakabayashi M;Sakasegawa N;Agawa S;Higuchi K;Akimoto T;Ueki N;Kawagoe T;Sato H;Nakatsuka K;Gudis K;Kawamoto C;Akamizu T;Sakamoto C;Iwakiri K
没有关于功能性消化不良（FD）和胰腺疾病之间重叠的可用数据。我们的目的是利用内超声检查来确定伴有胰酶异常的上腹痛综合征（EPS）是否与日本胰腺学会（JPS）提出的早期慢性胰腺炎相关。我们连续招募了 99 名具有 FD 典型症状的患者，包括根据罗马 III 标准，餐后窘迫综合征 (PDS) (n = 59)、伴有胰酶异常的 EPS (n = 41) 和无胰酶异常的 EPS (n = 42) 患者。使用 13C-乙酸呼气试验评估胃动力。通过内超声检查发现早期慢性胰腺炎，分级为0至7级。EPS患者中出现胰酶异常的女性患者比例(34/41)显着(p = 0.0018)高于无胰酶异常的女性EPS患者比例(20/42)。与无胰酶异常的 EPS 患者相比，餐后腹胀和身体成分总结 (PCS) 评分明显受到干扰。有趣的是，与无胰酶异常的 EPS 患者相比，AUC5 和 AUC15 值（分别为 24.85 ± 1.31 和 56.11 ± 2.51）也显着升高（分别为 p = 0.002 和 p = 0.001）（分别为 19.75 ± 1.01 和 47.02 ± 1.99）。总体而言，64% 患有胰酶异常的 EPS 患者通过内超声检查诊断为伴有 JPS 提出的早期慢性胰腺炎。需要进一步的研究来阐明胰酶异常的 EPS 患者与 JPS 提出的早期慢性胰腺炎之间的关系。
There was not available data about the overlap between functional dyspepsia (FD) and pancreatic diseases. We aimed to determine whether epigastric pain syndrome (EPS) accompanying with pancreatic enzyme abnormalities were associated with early chronic pancreatitis proposed by Japan Pancreas Society (JPS) using endosonography. We enrolled 99 consecutive patients presenting with typical symptoms of FD, including patients with postprandial distress syndrome (PDS) (n = 59), EPS with pancreatic enzyme abnormalities (n = 41) and EPS without pancreatic enzyme abnormalities (n = 42) based on Rome III criteria. Gastric motility was evaluated using the 13C-acetate breath test. Early chronic pancreatitis was detected by endosonography and graded from 0 to 7. The ratio of female patients among EPS patients (34/41) with pancreatic enzyme abnormalities was significantly (p = 0.0018) higher than the ratio of female EPS patients (20/42) without it. Postprandial abdominal distention and physical component summary (PCS) scores in EPS patients with pancreatic enzyme abnormalities were significantly disturbed compared to those in EPS patients without it. Interestingly, AUC5 and AUC15 values (24.85 ± 1.31 and 56.11 ± 2.51, respectively) in EPS patients with pancreatic enzyme abnormalities were also significantly (p = 0.002 and p = 0.001, respectively) increased compared to those (19.75 ± 1.01 and 47.02 ± 1.99, respectively) in EPS patients without it. Overall, 64% of EPS patients with pancreatic enzyme abnormalities were diagnosed by endosonography as having concomitant early chronic pancreatitis proposed by JPS. Further studies are warranted to clarify how EPS patients with pancreatic enzyme abnormalities were associated with early chronic pancreatitis proposed by JPS.
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DOI：
10.1111/j.1440-1746.2011.06627.x
发表时间：
2011-04-01
影响因子：
4.1
作者：
Kusano, Motoyasu;Zai, Hiroaki;Mori, Masatomo
通讯作者：
Mori, Masatomo
DOI：
10.1152/ajpgi.00086.2003
发表时间：
2004-02-01
影响因子：
4.5
作者：
Lee, KJ;Vos, R;Tack, J
通讯作者：
Tack, J
影响因子：
5.9
作者：
Peura, DA;Kovacs, TOG;Talley, NJ
通讯作者：
Talley, NJ
通过 13C 呼气试验测定健康受试者胃中液体和固体的排空时间：年龄、性别和体重指数的影响
DOI：
10.1111/j.1440-1746.2006.04449.x
发表时间：
2006-12-01
影响因子：
4.1
作者：
Hellmig, Stephan;Von Schoening, Florian;Stueber, Eckhard
通讯作者：
Stueber, Eckhard
影响因子：
158.5
作者：
McColl, K;Murray, L;Hilditch, T
通讯作者：
Hilditch, T