Coordination of Human Hippocampal Sharpwave Ripples during NREM Sleep with Cortical Theta Bursts, Spindles, Downstates, and Upstates
Coordination of Human Hippocampal Sharpwave Ripples during NREM Sleep with Cortical Theta Bursts, Spindles, Downstates, and Upstates
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DOI：
10.1523/jneurosci.2857-18.2019
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发表时间：
2019-10-30
影响因子：
5.3
通讯作者：
Halgren, Eric
中科院分区：
文献类型：
--
作者：
Jiang, Xi;Gonzalez-Martinez, Jorge;Halgren, Eric
在啮齿类动物中，清醒的放电模式重放NREM睡眠期间海马尖波波纹（HC-SWR），与新皮层图形元素（NC-GE）。NC-GE包括theta爆发、纺锤体、下状态和上状态。在人类中，睡眠期间的巩固与头皮记录的纺锤波和下状态/上状态相关，但HC-SWR无法无创记录。在这里，我们表明，在人类的两种性别，HC-SWRs高度相关的NC-GE在NREM，与显着更多的相关性HC-SWRs/NC-GE的下行或上行比theta爆发或纺锤波，在N2比N3，在后比前HC，在额叶比枕叶皮质，同侧比对侧。交互的偏好（例如，在N2中，额叶纺锤体经常与后部HC-SWR共同出现）。HC-SWR/NC-GE相互作用的这些优选GE、阶段和位置可能指示选择性整合活动，尽管在本研究中未进行测试。不同HC区域的SWR很少同时出现，并且与不同皮层区域的GE相关，表明HC-NC在多个短暂的、广泛的但离散的网络中相互作用。NC-GE倾向于与HC-SW Rs以及彼此之间具有一致的时间关系。皮层theta爆发通常在HC-SWR之前，它们可以帮助定义触发HC-SWR放电的皮层输入。HC-SWRs往往遵循皮质下状态发作，周围的局部降低宽带功率，这表明一种机制同步皮质，丘脑和海马的活动。广泛的皮质upstates和纺锤体遵循HC-SWRs，与假设的贡献由海马放电在HC-SWRs皮质放电模式在upstates和纺锤体。总的来说，我们的研究结果描述了海马和皮层振荡是如何协调在人类的事件是至关重要的记忆巩固在啮齿动物。
In rodents, waking firing patterns replay in NREM sleep during hippocampal sharpwave ripples (HC-SWRs), correlated with neocortical graphoelements (NC-GEs). NC-GEs include theta bursts, spindles, downstates, and upstates. In humans, consolidation during sleep is correlated with scalp-recorded spindles and downstates/upstates, but HC-SWRs cannot be recorded noninvasively. Here we show in humans of both sexes that HC-SWRs are highly correlated with NC-GEs during NREM, with significantly more related HC-SWRs/NC-GEs for downstates or upstates than theta bursts or spindles, in N2 than N3, in posterior than anterior HC, in frontal than occipital cortex, and ipsilaterally than contralaterally. The preferences interacted (e.g., frontal spindles co-occurred frequently with posterior HC-SWRs in N2). These preferred GEs, stages, and locations for HC-SWR/NC-GE interactions may index selective consolidation activity, although that was not tested in this study. SWR recorded in different HC regions seldom co-occurred, and were related to GE in different cortical areas, showingthat HC-NC interact in multiple transient, widespread but discrete, networks. NC-GEs tend to occur with consistent temporal relationships to HC-SW Rs, and to each other. Cortical theta bursts usually precede HC-SWRs, where they may help define cortical input triggering HC-SWR firing. HC-SWRs often follow cortical downstate onsets, surrounded by locally decreased broadband power, suggesting a mechanism synchronizing cortical, thalamic, and hippocampal activities. Widespread cortical upstates and spindles follow HC-SWRs, consistent with the hypothesized contribution by hippocampal firing during HC-SW Rs to cortical firing-patterns during upstates and spindles. Overall, our results describe how hippocampal and cortical oscillations are coordinated in humans during events that are critical for memory consolidation in rodents.