INCREASED ENDOTHELIN-1 CONTENT IN BLOOD-VESSELS OF DEOXYCORTICOSTERONE ACETATE SALT HYPERTENSIVE BUT NOT IN SPONTANEOUSLY HYPERTENSIVE RATS
INCREASED ENDOTHELIN-1 CONTENT IN BLOOD-VESSELS OF DEOXYCORTICOSTERONE ACETATE SALT HYPERTENSIVE BUT NOT IN SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.1161/01.hyp.21.3.294
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发表时间：
1993-03-01
期刊：
影响因子：
8.3
通讯作者：
SCHIFFRIN, EL
中科院分区：
文献类型：
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作者：
LARIVIERE, R;THIBAULT, G;SCHIFFRIN, EL
内皮素-1（Endothelin-1，ET-1）是由血管内皮细胞产生的一种强缩血管活性肽，可能在高血压的发病机制中发挥重要作用。我们研究了免疫反应性ET-1（ir-ET-1）的水平，从血管的脱氧皮质酮醋酸盐（DOCA）-盐和自发性高血压大鼠的酸提取物。我们发现胸主动脉段和肠系膜血管床的ir-ET-1含量（分别为11.84+/-0.84和17.30+/-1.89 fmol）显著高于单侧肾切除对照组大鼠（分别为1.78+/-0.20和9.19+/-0.63 fmol; p
Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide produced in the endothelium of blood vessels that may play an important role in the control of local blood How and could be involved in the pathogenesis of hypertension. We investigated immunoreactive ET-1 (ir-ET-1) levels in acid extracts from blood vessels of deoxycorticosterone acetate (DOCA)-salt and spontaneously hypertensive rats. We found that segments of thoracic aorta and the mesenteric vascular bed contain significantly more ir-ET-1 (11.84+/-0.84 and 17.30+/-1.89 fmol, respectively) than uninephrectomized control rats (1.78+/-0.20 and 9.19+/-0.63 fmol, respectively; p