Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival crevicular fluid in post-menopausal women with chronic periodontitis
Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival crevicular fluid in post-menopausal women with chronic periodontitis
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DOI：
10.1111/j.1600-051x.2006.00923.x
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发表时间：
2006-06-01
影响因子：
6.7
通讯作者：
Karabulut, E
中科院分区：
文献类型：
--
作者：
Baltacioglu, E;Akalin, FA;Karabulut, E
目的：绝经与氧化应激和抗氧化剂(AO)防御能力降低有关。更年期和某些牙周疾病之间已经建立了联系。本研究旨在比较绝经后慢性牙周炎(PMCP)患者与绝经前慢性牙周炎(CP)患者血清及龈沟液(GCF)总抗氧化能力(TAOC)和超氧化物歧化酶(SOD)含量的差异。材料和方法：对32例PMCP患者、31例CP患者、25例绝经后牙周健康对照(PMPH)和26例绝经前对照(PH)进行比较。在临床测量和采样后，使用自动TAOC测定法和分光光度终点测量法依次建立血清和GCF的TAOC和SOD浓度。结果：绝经组和牙周炎组血清和牙周液中总抗氧化能力和超氧化物歧化酶含量均显著低于对照组(p<；0.05)。PMCP组最低，PH组最高。绝经对血清抗氧化能力的影响更明显，而牙周炎对牙周炎的影响更明显。结论：绝经和牙周炎均降低了全身和局部的AO防御能力。PMCP组的AO值最低，提示绝经可能是牙周炎的危险因素。
Objectives: Menopause has been linked with oxidative stress and decreased antioxidant (AO) defence. A connection has been established between menopause and certain periodontal conditions. The objective of this study is to compare serum and gingival crevicular fluid (GCF) total antioxidant capacity (TAOC) and superoxide dismutase (SOD) concentrations in post-menopausal patients with chronic periodontitis (PMCP) with those of pre-menopausal chronic periodontitis patients (CP).Materials and Methods: Thirty-two PMCP patients, 31 CP patients, 25 post-menopausal periodontally healthy controls (PMPH) and 26 pre-menopausal controls (PH) were studied. After clinical measurements and samplings, serum and GCF TAOC and SOD concentrations were established in turn using an automated TAOC assay and spectrophotometric end point measurement. The results were analysed statistically.Results: Serum and GCF TAOC and SOD concentrations were significantly lower in menopause and periodontitis (p < 0.05). The lowest values were in the PMCP group, whereas the highest values were in the PH group. While the effect of menopause was more evident in serum antioxidant analysis, the effect of periodontitis was observed to be more apparent in GCF.Conclusions: A decrease in systemic and local AO defence was observed owing to both menopause and periodontitis. The lowest AO values in the PMCP group suggest that menopause may be a risk factor for periodontitis.