Defining dosing pattern characteristics of successful tapers following methadone maintenance treatment: results from a population-based retrospective cohort study
Defining dosing pattern characteristics of successful tapers following methadone maintenance treatment: results from a population-based retrospective cohort study
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DOI：
10.1111/j.1360-0443.2012.03870.x
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发表时间：
2012-09-01
期刊：
影响因子：
6
通讯作者：
Anis, Aslam H.
中科院分区：
文献类型：
--
作者：
Nosyk, Bohdan;Sun, Huiying;Anis, Aslam H.
目的 确定与美沙酮维持治疗 (MMT) 后持续成功相关的剂量逐渐减少策略。设计基于人群的回顾性队列研究。设置来自加拿大不列颠哥伦比亚省的关联行政药物分配数据。参与者 1996 年至 2006 年期间，完成了 25 545 次 MMT 治疗，其中 14 602 次开始逐渐减量，其中 4 183 人（占 4 917 次 MMT 治疗）符合研究纳入标准。测量 主要结果是持续成功减量，定义为治疗发作最后一周每日剂量 = 5 mg，并且在发作完成后 18 个月内没有再次治疗、阿片类药物相关住院或死亡。结果 在符合纳入标准的发作中（4917 例中的 646 例），持续成功的总体率为 13%；在所有开始逐渐减量的发作中，持续成功率为 4.4%（14 602 例中的 646 例）；在数据集中所有已完成的发作中，持续成功率为 2.5%（25 545 例中的 646 例）。我们的多变量逻辑回归分析结果表明，较长的减量手术成功率要高得多[1252 周 vs 52 周 vs
Aims To identify dose-tapering strategies associated with sustained success following methadone maintenance treatment (MMT). Design Population-based retrospective cohort study. Setting Linked administrative medication dispensation data from British Columbia, Canada. Participants From 25 545 completed MMT episodes, 14 602 of which initiated a taper, 4183 individuals (accounting for 4917 MMT episodes) from 1996 to 2006 met study inclusion criteria. Measurements The primary outcome was sustained successful taper, defined as a daily dose =5 mg per day in the final week of the treatment episode and no treatment re-entry, opioid-related hospitalization or mortality within 18 months following episode completion. Findings The overall rate of sustained success was 13% among episodes meeting inclusion criteria (646 of 4917), 4.4% (646 of 14 602) among all episodes initiating a taper and 2.5% (646 of 25 545) among all completed episodes in the data set. The results of our multivariate logistic regression analyses suggested that longer tapers had substantially higher odds of success [1252 weeks versus 52 weeks versus