AMPHETAMINE, COCAINE, PHENCYCLIDINE AND NOMIFENSINE INCREASE EXTRACELLULAR DOPAMINE CONCENTRATIONS PREFERENTIALLY IN THE NUCLEUS ACCUMBENS OF FREELY MOVING RATS
AMPHETAMINE, COCAINE, PHENCYCLIDINE AND NOMIFENSINE INCREASE EXTRACELLULAR DOPAMINE CONCENTRATIONS PREFERENTIALLY IN THE NUCLEUS ACCUMBENS OF FREELY MOVING RATS
复制标题
DOI：
10.1016/0306-4522(89)90012-2
复制
发表时间：
1989-01-01
期刊：
影响因子：
3.3
通讯作者：
DICHIARA, G
中科院分区：
文献类型：
--
作者：
CARBONI, E;IMPERATO, A;DICHIARA, G
通过伏隔核和背侧尾状核的微透析来评估全身施用安非他明、可卡因、苯环己哌啶和诺米芬辛对自由活动大鼠的细胞外多巴胺浓度的影响。所有测试的药物都会刺激这两个区域的多巴胺输出，但与尾状核相比，伏隔核的多巴胺输出更有效。低剂量的可卡因（1.0 mg/kg s.c.）仅刺激伏隔核中的多巴胺输出。诺米芬辛（1.25-5.0 mg/kg s.c.）在两个多巴胺能区域中的峰值多巴胺输出增加了类似程度，但与尾状核相比，伏隔核中的作用持续时间更长。可卡因、苯环己哌啶和诺米芬辛的作用被全身性γ-丁内酯(700mg/kg i.p.)阻止，并且通过从用于透析的林格氏液中省略Ca2+，安非他明的作用对这些操作不敏感。因此，与安非他明相反，可卡因、苯环己哌啶和诺米芬辛通过依赖于多巴胺能神经元的完整活性的机制和通过胞吐过程增加体内突触多巴胺浓度。
The effect of systemically administered amphetamine, cocaine, phencyclidine and nomifensine on the extracellular concentrations of dopamine in freely moving rats was estimated by microdialysis in the nucleus accumbens and in the dorsal caudate. All the drugs tested stimulated dopamine output in both areas but more effectively in the accumbens as compared to the caudate. Low doses of cocaine (1.0 mg/kg s.c.) stimulated dopamine output only in the nucleus accumbens. Nomifensine (1.25-5.0 mg/kg s.c.) increased by a similar extent peak dopamine output in the two dopaminergic areas but the duration of the effect was longer in the accumbens as compared to the caudate. The effect of cocaine, phencyclidine and nomifensine was prevented by systemic .gamma.-butyrolactone (700 mg/kg i.p.) and by omitting Ca2+ from the Ringer used for dialysis, the effect of amphetamine was insensitive to these manipulations. Thus, in contrast with amphetamine, cocaine, phencyclidine and nomifensine increase synaptic dopamine concentrations in vivo by a mechanism which depends on intact activity of dopaminergic neurons and by an exocytotic process.