Development of the Lamprey Central Nervous System, with Reference to Vertebrate Evolution
Development of the Lamprey Central Nervous System, with Reference to Vertebrate Evolution
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DOI：
10.2108/zsj.25.1020
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发表时间：
2008-10
期刊：
影响因子：
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通讯作者：
A. Watanabe;S. Hirano;Y. Murakami
中科院分区：
文献类型：
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作者：
A. Watanabe;S. Hirano;Y. Murakami
摘要脊椎动物的大脑是高度组织化的结构，在动物群体中表现出显着的多样性。在脊椎动物进化的早期，无脊椎动物从节口动物分化而来，在阐明大脑的起源和进化方面占据了关键的系统发育地位。我们对七鳃鳗脑的发育进行了研究，并将其发育计划与脊椎动物的发育计划进行了比较，以期重建脊椎动物脑的进化过程。我们发现七鳃鳗脑具有形成神经聚合体隔室所需的基本分子机制，其中脑和间脑具有保守的形态和分子特征。相反，端脑和后脑表现出七鳃鳗特有的发育机制。因此，神经系统的分子程序被认为在颌口血统中得到了改进。一些调控基因表达结构域的变化可能促进了脊椎动物中枢神经系统的进化。
Abstract Vertebrate brains are highly organized structures that show remarkable diversity throughout animal groups. The agnathans, which diverged from the gnathostomes early in the evolution of the vertebrates, occupy a key phylogenetic position from which to clarify the origin and evolution of the brain. We studied the developing lamprey brain and compared its developmental plan with that of the gnathostomes, in order to reconstruct the evolutionary processes of the vertebrate brain. We found that the lamprey brain has the basic molecular mechanisms necessary to form neuromeric compartments, and that its mesencephalon and diencephalon exhibit conserved morphological and molecular features. Conversely, the telencephalon and metencephalon display lamprey-specific developmental mechanisms. Thus, the molecular program of the nervous system is thought to have improved in the gnathostome lineage. Changes in the expression domains of some regulatory genes might have facilitated the evolution of the vertebrate central nervous system.