Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy
Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy
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DOI：
10.1034/j.1399-3038.2002.01093.x
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发表时间：
2002-12-01
影响因子：
4.4
通讯作者：
Lemanske, RF
中科院分区：
文献类型：
--
作者：
Gern, JE;Martin, MS;Lemanske, RF
病毒对呼吸道组织的损伤和白细胞介素8(IL-8)等促炎细胞因子的诱导都可能导致儿童病毒性呼吸道感染的症状严重程度。为了验证IL-8在儿童自然获得性呼吸道病毒感染时引起呼吸道症状的作用这一假设，对198例急性病毒感染婴儿和31例健康未感染婴儿的鼻腔冲洗标本进行了IL-8检测。未感染儿童鼻腔冲洗液IL-8水平与年龄呈正相关(r(S)=0.36，p流感，p
Both virus-mediated damage to airway tissues and induction of pro-inflammatory cytokines such as interleukin-8 (IL-8) could contribute to symptom severity during viral respiratory infections in children. To test the hypothesis that IL-8 contributes to the pathogenesis of respiratory symptoms during naturally acquired respiratory viral infections in children, nasal wash samples collected from infants with acute viral infections (n=198) or from healthy uninfected infants (n=31) were analysed for IL-8. Nasal wash IL-8 was positively related to age in uninfected children (r(s)=0.36, pinfluenza, p