Changes in choroidal thickness and optical axial length accompanying intraocular pressure increase
Changes in choroidal thickness and optical axial length accompanying intraocular pressure increase
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DOI：
10.1007/s10384-012-0173-0
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发表时间：
2012-11-01
影响因子：
2.4
通讯作者：
Kurimoto, Yasuo
中科院分区：
文献类型：
--
作者：
Hata, Masayuki;Hirose, Fumitaka;Kurimoto, Yasuo
为测量眼内压（IOP）升高时脉络膜厚度（CT）、视网膜厚度（RT）和眼轴长度（AL）的变化，探讨IOP升高引起眼轴尺寸的变化，对34例（34只眼）原发性房角关闭（PAC）患者进行了诊断性激发试验。排除其他黄斑疾病患者。患者接受暗室俯卧激发试验（DR-PPT）1 h。我们通过光学相干断层扫描（OCT）和增强深度成像方法测量了中心凹的CT和RT，DR-PPT前后的部分相干激光干涉测量。平均（SD）IOP增加7.3，具有统计学显著性DR-PPT后的平均（SD）AL为0.06（0.12）mm（分别为P < 0.001和P = 0.014）。中心凹下CT平均值（SD）降低30.0，具有统计学意义（36.8）μ m中心凹RT无明显变化，中心凹下CT变化与眼压变化呈负相关在怀疑患有PAC的眼中，眼压急性升高伴随脉络膜变薄和相应的光轴延长。
To measure changes in choroidal thickness (CT), retinal thickness (RT), and axial length (AL) accompanying intraocular pressure (IOP) increase and to investigate the changes in axial eye dimensions induced by IOP increase.Thirty-four eyes of 34 patients undergoing a diagnostic provocative test for primary angle closure (PAC). Patients with other macular diseases were excluded. Patients underwent the darkroom prone provocative test (DR-PPT) for 1 h. We measured CT and RT at the fovea by optical coherence tomography with the enhanced depth imaging method and AL with noncontact, partial coherence laser interferometry before and after the DR-PPT.There was a statistically significant increase in the mean (SD) IOP of 7.3 (9.2) mmHg and the mean (SD) AL of 0.06 (0.12) mm after the DR-PPT (P < 0.001 and P = 0.014, respectively). There was a statistically significant decrease in the mean (SD) subfoveal CT of 30.0 (36.8) mu m (P < 0.001), while there was no significant change in the mean foveal RT. The change in subfoveal CT was negatively correlated with the changes in IOP (r = -0.71, P < 0.001) and AL (r = -0.54, P = 0.004).In eyes suspected of having PAC, acutely increased IOP accompanies choroid thinning and corresponding elongation of the optical axis.