Characteristics of autoimmunity in type 1 diabetes and type 1.5 overlap with type 2 diabetes.
Characteristics of autoimmunity in type 1 diabetes and type 1.5 overlap with type 2 diabetes.
复制标题
1 型糖尿病和 1.5 型糖尿病的自身免疫特征与 2 型糖尿病重叠。
DOI：
10.2337/diabetes.54.suppl_2.s4
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发表时间：
2005
期刊：
影响因子：
7.7
通讯作者：
H. Mcdevitt
中科院分区：
文献类型：
--
作者：
H. Mcdevitt
本报告概述了哺乳动物发展和维持自身耐受性的机制。由于本次会议的重点是1型糖尿病及其机制，讨论主要涉及T细胞耐受的机制，因为1型糖尿病在效应期和启动期都主要是一种T细胞介导的自身免疫性疾病。重点放在最近发现的维持自我耐受的机制(自身免疫调节器[AIRE])和T细胞阴性选择的新缺陷上。出现的图景是一种多基因疾病，具有许多基因的不同等位基因的不同组合，在正常免疫反应或正常免疫反应中发挥重要作用。
This presentation is an overview of mechanisms for developing and maintaining self-tolerance in mammalian organisms. Because this meeting is focused on type 1 diabetes and its mechanisms, the discussion deals primarily with mechanisms of T-cell tolerance, since type 1 diabetes in both effector and initiator phases is primarily a T-cell-mediated autoimmune disease. Emphasis is placed on more recently discovered mechanisms of maintaining self-tolerance (autoimmune regulator [AIRE]) and a new defect in T-cell negative selection. The emerging picture is that of a polygenic disease with various combinations of different alleles of many genes with important roles in the normal immune response or normal immune responses.