The genetics of otitis media.
The genetics of otitis media.
复制标题
DOI：
10.1007/s11882-002-0055-5
复制
发表时间：
2002-07-01
影响因子：
5.5
通讯作者：
Post, J Christopher
中科院分区：
文献类型：
--
作者：
Goodwin, Joseph H;Post, J Christopher
几乎每个孩子都会遭受至少一次中耳炎（OM）发作。因此，它不是立即明显的，有一个遗传易感性的疾病的发展。然而，来自各种研究的证据表明，有一个明确的遗传因素对OM的易感性。本文描述了发现这些基因的方法。OM易感基因的鉴定允许开发分子诊断测定，其将告知临床医生哪个儿童处于增加的风险中，并保证更积极的干预。描述OM基因不仅提供了对这种常见疾病的病理生理学的更深入的理解，而且还提供了对一般急性和慢性细菌性疾病的更深入的理解。
Almost every child will suffer at least one episode of otitis media (OM). Therefore, it is not immediately obvious that there is a genetic predisposition to the development of the disease. However, evidence from a variety of studies has shown that there is a clear genetic component to susceptibility to OM. Methodologies for discovering these genes are described within this article. The identification of OM susceptibility genes allows the development of molecular diagnostic assays that will inform the clinician as to which child is at increased risk and warrants more aggressive intervention. Delineating the OM genes not only provides a deeper understanding of the pathophysiology of this common disease, but also of acute and chronic bacterial disease in general.