Dynamic Epidemiology of Acute Viral Hepatitis in Japan
Dynamic Epidemiology of Acute Viral Hepatitis in Japan
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DOI：
10.1159/000252788
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发表时间：
2010-01-01
期刊：
影响因子：
4.6
通讯作者：
Ishibashi, Hiromi
中科院分区：
文献类型：
--
作者：
Yano, Koji;Tamada, Yoko;Ishibashi, Hiromi
急性病毒性肝炎（AVH）的流行病学是动态的，受卫生、社会经济状况和疫苗接种覆盖率等诸多因素的影响。在1980年至2008年期间，共有4302例AVH患者被纳入这项全国性研究。AVH中，急性甲型肝炎（AHA） 1583例（36.8%），急性乙型肝炎（AHB） 1197例（27.8%），急性丙型肝炎（AHC） 359例（8.3%），非A、非B、非C (non-ABC) 1163例（27.0%）。1980 ~ 1995年，AHA、AHB、AHC和非abc的比例分别约为40%、25%、10%和25%；从1996年到2003年，这一比例分别为30%、30%、10%和30%，在过去5年里，这一比例转变为10%、40%、10%和40%。由非日本本土基因型A引起的AHB数量在1991年至1996年期间为6.0%，但自2000年以来显著增加，2008年达到52%。2002年以后，本地急性戊型肝炎（AHE）占非abc型肝炎的10-15%。在日本，AVH的病因已经发生了巨大的变化。AHB基因型A的显著增加和自体AHE的持续发生需要引起重视，并采取必要的措施。版权所有：S. Karger AG，巴塞尔
The epidemiology of acute viral hepatitis (AVH) is dynamic and affected by many factors including hygiene, socioeconomic status and vaccination coverage. A total of 4,302 cases of AVH were sequentially enrolled in this nationwide study between 1980 and 2008. Of the cases of AVH, acute hepatitis A (AHA) accounted for 1,583 (36.8%), acute hepatitis B (AHB) for 1,197 (27.8%), acute hepatitis C (AHC) for 359 (8.3%), and non-A, non-B and non-C (non-ABC) for 1,163 (27.0%). Between 1980 and 1995, the proportions of AHA, AHB, AHC and non-ABC were approximately 40, 25, 10 and 25%; between 1996 and 2003, they were approximately 30, 30, 10 and 30%, and this shifted to approximately 10, 40, 10 and 40% in the last 5 years. The number of AHB caused by genotype A, which is not indigenous to Japan, was 6.0% between 1991 and 1996 but has been markedly increasing since 2000, to reach 52% in 2008. Autochthonous acute hepatitis E (AHE) accounted for 10-15% of non-ABC hepatitis after 2002. The etiology of AVH in Japan has been drastically changing. A marked increase of AHB genotype A and constant occurrence of autochthonous AHE require attention, and necessary measures should be taken. Copyright (C) 2010 S. Karger AG, Basel