The use of corticosteroids to treat keloids: a review.
The use of corticosteroids to treat keloids: a review.
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DOI：
10.1177/1534734608320786
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发表时间：
2008-09-01
期刊：
影响因子：
--
通讯作者：
Teot, Luc
中科院分区：
文献类型：
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作者：
Roques, Claude;Teot, Luc
瘢痕疙瘩形成的机制包括生长因子作用、胶原蛋白周转、施加在皮肤上的机械力以及遗传和免疫作用的急剧变化。使用皮质类固醇治疗瘢痕疙瘩增加了碱性成纤维细胞生长因子的产生，同时减少了人真皮成纤维细胞、内源性血管内皮生长因子和胰岛素样生长因子-1的转化生长因子-β 1的产生。皮质类固醇注射的使用，迄今为止，核心治疗可用于管理过多的组织生产的疤痕。目前，最有效和安全的治疗瘢痕疙瘩的方案似乎是使用皮质激素治疗-手术切除后皮内注射类固醇。
Mechanisms for keloid formation include drastic changes in growth factor actions, collagen turnover, mechanical forces applied over the skin, and genetic and immunologic contributions. The use of corticosteroids to manage keloids increases basic fibroblast growth factor production while decreasing transforming growth factor-beta1 production by human dermal fibroblasts, endogenous vascular endothelial growth factor, and insulin-like growth factor-1. The use of corticosteroid injections is, to date, the core treatment available for the management of excessive tissue production in scars. Currently, the most effective and safe regimen for keloid management appears to be the use of corticotherapy-injection of intradermal steroids after a surgical excision.