Corticospinal output during muscular fatigue differs in multiple sclerosis patients compared to healthy controls
Corticospinal output during muscular fatigue differs in multiple sclerosis patients compared to healthy controls
复制标题
与健康对照相比，多发性硬化症患者肌肉疲劳期间的皮质脊髓输出有所不同
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
KM Rösler
中科院分区：
文献类型：
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作者：
O. Scheidegger;CP Kamm;SJ Humpert;KM Rösler
背景：在多发性硬化症（MS）中，疲劳是一种常见且经常致残的症状。其病因是多方面的，其中中枢运动疲劳起着重要作用。目的：本研究的目的是分析MS患者与健康对照组相比，在肌肉疲劳和恢复期间与肌肉收缩力相关的中枢运动传导变化。研究方法：共23名MS患者疲劳和13名健康受试者进行了评估，在2分钟的疲劳运动的小指展肌的手和随后的7分钟的恢复。通过经颅磁刺激使用三重刺激方案并计算中枢传导指数（CCI）来量化中枢运动传导。结果如下：在MS患者中，力量下降到运动前水平的36%（SD 16%; p < 0.01），在健康受试者中下降到44%（SD 9%，p < 0.01）（组间差异，无统计学意义）。与健康受试者（-57%，SD15%，p < 0.05;组间差异，p <0.05）相比，患者（-20%，SD26%，p <0.05）的CCI下降明显较低。两组的力量下降与CCI无关。结论：在疲劳运动期间，MS患者的中枢运动传导的下降明显不如健康受试者明显，尽管力量的减少是相似的。
Background: In multiple sclerosis (MS), fatigue is a common and often disabling symptom. It has multiple causes with central motor fatigue playing an important role. Objective: The objective of this study was to analyse the central motor conduction changes in relation to muscle contraction force during muscle fatigue and recovery in MS patients compared to healthy controls. Methods: A total of 23 MS patients with fatigue and 13 healthy subjects were assessed during 2 minutes of fatiguing exercise of the abductor digiti minimi muscle of the hand and the subsequent 7 minutes of recovery. Central motor conduction was quantified by transcranial magnetic stimulation using the triple stimulation protocol and calculating a central conduction index (CCI). Results: Force declined to 36% of the pre-exercise level (SD 16%; p < 0.01) in MS patients and to 44% (SD 9%, p < 0.01) in healthy subjects (group differences, not statistically significant). The decline of the CCI was significantly less marked in patients (–20%, SD 26%, p < 0.05) than in healthy subjects (–57%, SD 15%, p < 0.05; group differences, p < 0.05). The decline of force and CCI were not correlated in either group. Conclusions: During a fatiguing exercise, the decline in central motor conduction is significantly less pronounced in MS patients than healthy subjects, although the reduction of force is similar.
影响因子：
158.5
作者：
Trapp, BD;Peterson, J;Bö, L
通讯作者：
Bö, L