Synchronization and Enhanced Catalysis of Mechanically Coupled Enzymes
Synchronization and Enhanced Catalysis of Mechanically Coupled Enzymes
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DOI：
10.1103/physrevlett.127.208103
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发表时间：
2021-11-12
影响因子：
8.6
通讯作者：
Golestanian, Ramin
中科院分区：
文献类型：
--
作者：
Agudo-Canalejo, Jaime;Adeleke-Larodo, Tunrayo;Golestanian, Ramin
我们研究了两种酶的随机动力学，它们相互机械耦合，例如，通过弹性基底或流体介质。酶在其催化循环期间经历构象变化，其本身由随机步骤沿着有偏的化学自由能景观驱动。我们发现的条件下，酶可以同步其催化步骤，并发现耦合可以导致显着提高其整体催化速率。这两种效应都可以理解为在足够强的耦合下，底层动力系统的全局分叉。我们的研究结果表明，尽管它们的分子规模，酶可以合作，并提高其在代谢集群的性能。
We examine the stochastic dynamics of two enzymes that are mechanically coupled to each other, e.g., through an elastic substrate or a fluid medium. The enzymes undergo conformational changes during their catalytic cycle, which itself is driven by stochastic steps along a biased chemical free energy landscape. We find conditions under which the enzymes can synchronize their catalytic steps, and discover that the coupling can lead to a significant enhancement in their overall catalytic rate. Both effects can be understood as arising from a global bifurcation in the underlying dynamical system at sufficiently strong coupling. Our findings suggest that, despite their molecular scale, enzymes can be cooperative and improve their performance in metabolic clusters.