Zinc sulphate solution enema decreases inflammation in experimental colitis in rats
Zinc sulphate solution enema decreases inflammation in experimental colitis in rats
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DOI：
10.1046/j.1440-1746.1999.02013.x
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发表时间：
1999-11-01
影响因子：
4.1
通讯作者：
Liu, XG
中科院分区：
文献类型：
--
作者：
Chen, BW;Wang, HH;Liu, XG
背景资料：据报道，硫酸锌在许多动物模型中具有抗炎作用;然而，锌在结肠炎中的影响仍不清楚。方法：用2，4，6-三硝基苯磺酸（TNB）诱发大鼠结肠炎，观察硫酸锌对实验性结肠炎的治疗作用。从TNB结肠炎的第一天开始，每天一次用硫酸锌灌肠剂处理大鼠，持续6天。结果：TNB可引起大鼠严重的结肠炎，表现为黏膜损伤面积、黏膜髓过氧化物酶（MPO）活性、前列腺素E2（PGE 2）和白三烯B 4（LTB 4）含量增加。应用硫酸锌灌肠后6天，粘膜病变面积、MPO活性、PGE（2）和LTB 4水平均显著降低。粘多糖超氧化物歧化酶活性保持不变后，锌treatments.Conclusions：我们的数据表明，硫酸锌灌肠剂对实验性结肠炎有抗炎作用。(C)1999 Blackwell Science Asia Pty Ltd.
Background: It has been reported that zinc sulphate contributes an anti-inflammatory action in many animal models; however, the impact of zinc in colitis remains unclear. The aim of the present study was to examine the role of zinc sulphate in experimental colitis.Methods: Colitis was induced by 2,4,6-trinitrobenzenesulphonic acid (TNB) in rats. Beginning at the first day of TNB colitis, the rats were treated with a zinc sulphate enema once daily for 6 days. The rats were examined 8 days later.Results: The TNB induced severe colitis as evidenced by increased mucosal lesion area, mucosal myeloperoxidase (MPO) activity and prostaglandin E-2 (PGE(2)) and leukotriene B-4 (LTB4) levels. Six days after the application of the zinc sulphate enema, the mucosal lesion area, MPO activity, PGE(2) and LTB4 levels all decreased significantly. Mucosal superoxide dismutase activity remained unchanged after zinc treatments.Conclusions: Our data suggest that zinc sulphate enemas have an anti-inflammatory action on experimental colitis. (C) 1999 Blackwell Science Asia Pty Ltd.