Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene
Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene
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DOI：
10.1111/j.1600-0625.2012.01514.x
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发表时间：
2012-07
影响因子：
3.6
通讯作者：
Tomoko Sugawara;K. Nemoto;Y. Adachi;Nozomi Yamano;N. Tokuda;M. Muto;R. Okuyama;S. Sakai;Y. Owada
中科院分区：
文献类型：
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作者：
Tomoko Sugawara;K. Nemoto;Y. Adachi;Nozomi Yamano;N. Tokuda;M. Muto;R. Okuyama;S. Sakai;Y. Owada
Fatty acid binding proteins (FABPs) are capable of binding long‐chain FA and are involved in intracellular FA transport and signal transduction. In sebaceous glands, FABP5 is highly expressed in differentiated sebocytes; though, its function remains unclear. In this study, we examined the role of FABP5 in sebocytes using FABP5‐deficient mice. The size of sebaceous glands was significantly reduced, while the sebum volume was increased with altered lipid composition in FABP5‐deficient mice. However, no significant differences were discerned in the expression of proliferation or differentiation markers including Blimp1, c‐myc, Ki67 and peroxisome proliferator‐activated receptors (PPAR)γ between wild‐type and FABP5‐deficient sebaceous glands. The expression of cellular retinoic acid binding protein‐2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5‐deficient mice. These results suggest that FABP5 is involved in the regulation of sebaceous gland activity through modulation of cellular lipid signalling and/or metabolism in the sebocytes.
