EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles.
EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles.
复制标题
DOI：
10.3402/jev.v2i0.20384
复制
发表时间：
2013
影响因子：
16
通讯作者：
Gho YS
中科院分区：
文献类型：
--
作者：
Kim DK;Kang B;Kim OY;Choi DS;Lee J;Kim SR;Go G;Yoon YJ;Kim JH;Jang SC;Park KS;Choi EJ;Kim KP;Desiderio DM;Kim YK;Lötvall J;Hwang D;Gho YS
细胞外囊泡的分泌是一种普遍的细胞活动，其范围从简单的单细胞生物（例如古细菌;革兰氏阳性和革兰氏阴性细菌）到复杂的多细胞生物，表明这种细胞外囊泡介导的通信在进化上是保守的。细胞外囊泡是平均直径为20- 1，000 nm的球形双层蛋白脂质，已知其含有各种生物活性分子，包括蛋白质、脂质和核酸。在这里，我们提出了EVpedia，这是一个集成的数据库的高通量数据集从原核和真核细胞外囊泡。EVpedia提供了存在于原核生物、非哺乳动物真核生物和哺乳动物细胞外囊泡上的囊泡组分（蛋白质、mRNA、miRNA和脂质）的高通量数据集。此外，EVpedia还提供了一系列工具，如囊泡组分的搜索和浏览，基因本体富集分析，囊泡蛋白和mRNA的网络分析，以及通过直系同源物鉴定比较囊泡数据集。此外，数据库中还列出了关于细胞外囊泡研究的出版物。EVpedia（http：//www.example.com）的这个免费的基于网络的数据库可以作为促进细胞外囊泡研究的进步和阐明这些复杂的细胞外细胞器的新功能的基础知识库。evpedia.info
Secretion of extracellular vesicles is a general cellular activity that spans the range from simple unicellular organisms (e.g. archaea; Gram-positive and Gram-negative bacteria) to complex multicellular ones, suggesting that this extracellular vesicle-mediated communication is evolutionarily conserved. Extracellular vesicles are spherical bilayered proteolipids with a mean diameter of 20–1,000 nm, which are known to contain various bioactive molecules including proteins, lipids, and nucleic acids. Here, we present EVpedia, which is an integrated database of high-throughput datasets from prokaryotic and eukaryotic extracellular vesicles. EVpedia provides high-throughput datasets of vesicular components (proteins, mRNAs, miRNAs, and lipids) present on prokaryotic, non-mammalian eukaryotic, and mammalian extracellular vesicles. In addition, EVpedia also provides an array of tools, such as the search and browse of vesicular components, Gene Ontology enrichment analysis, network analysis of vesicular proteins and mRNAs, and a comparison of vesicular datasets by ortholog identification. Moreover, publications on extracellular vesicle studies are listed in the database. This free web-based database of EVpedia (http://evpedia.info) might serve as a fundamental repository to stimulate the advancement of extracellular vesicle studies and to elucidate the novel functions of these complex extracellular organelles.