Scintigraphy in prediction of the salivary gland function after gland-sparing intensity modulated radiation therapy for head and neck cancer
Scintigraphy in prediction of the salivary gland function after gland-sparing intensity modulated radiation therapy for head and neck cancer
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DOI：
10.1016/j.radonc.2008.02.017
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发表时间：
2008-05-01
影响因子：
5.7
通讯作者：
Saarilahti, Kauko
中科院分区：
文献类型：
--
作者：
Tenhunen, Mikko;Collan, Juhani;Saarilahti, Kauko
背景和目的：为了评估唾液腺造影在预测放射治疗后的唾液流Patients和方法：20例诊断为头颈部癌症的患者进行了调强放射治疗，目的是保留唾液腺功能。分别于治疗前、治疗后6个月和12个月测定唾液分泌总量，并采用99 mTc-高锝酸盐放射性造影监测大涎腺功能。设计了两种模型用于预测治疗后唾液流量：平均模型，基于健康受试者中四个主要腺体中的每一个产生的唾液的平均比例，以及个体模型，基于治疗前通过唾液描记术测量的每个腺体产生的唾液。这些模型进行了比较，以体积为基础的（莱曼）正常组织并发症的概率模型，使用两个已公布的模型parameters.Results集：腮腺和颌下腺功能的D-50在放疗后6个月和12个月评估约为39戈伊。基于唾液流图的个体模型很好地预测了测量的治疗后唾液流速。预测的刺激和测量的唾液流速之间的相关系数在放疗完成后6个月为0.77（p < 0.0001），在12个月为0.55（p = 0.034）。未受刺激和刺激的唾液流率的相对变化表现出类似的依赖于累积的辐射dose.Conclusions：唾液腺功能评估放射治疗前的放射治疗后的残留唾液流的预测是有用的。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Background and purpose: To evaluate salivary gland scintigraphy in prediction of salivary flow following radiation therapy.Patients and methods: Twenty patients diagnosed with head and neck cancer were treated with intensity modulated radiation therapy with an intention to spare the salivary gland function. The total quantitative saliva secretion was measured prior to and 6 and 12 months after therapy, and the function of the major salivary glands was monitored using Tc-99m-pertechnetate scintigraphy. Two models were designed for prediction of the post-treatment salivary flow: an average model, based on the average proportions of saliva produced by each of the four major glands in healthy subjects, and an individual model, based on saliva produced by each gland as measured by scintigraphy prior to therapy. These models were compared with volume-based (Lyman) normal tissue complication probability models using two published sets of model parameters.Results: The D-50 for the parotid and the submandibular gland function assessed at 6 and 12 months after radiotherapy was approximately 39 Gy. The scintigraphy-based individual model predicted well the measured post-treatment saliva flow rates. The correlation coefficient between the predicted stimulated and the measured saliva flow rate was 0.77 (p < 0.0001) at 6 months and 0.55 (p = 0.034) at 12 months after completion of radiotherapy. The relative changes in unstimulated and stimulated salivary flow rates showed similar dependency on the cumulative radiation dose.Conclusions: Salivary gland function assessed by scintigraphy prior to radiotherapy is useful in prediction of the residual salivary flow after radiotherapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved.