Organochlorines and breast cancer risk
Organochlorines and breast cancer risk
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DOI：
10.3322/canjclin.52.5.301
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发表时间：
2002-09-01
影响因子：
254.7
通讯作者：
Thun, MJ
中科院分区：
文献类型：
--
作者：
Calle, EE;Frumkin, H;Thun, MJ
有机氯是一组不同的合成化学品，包括多氯联苯（pcb）、二恶英和有机氯农药，如二氯二苯三氯乙烷（DDT）、林丹和六氯苯。尽管自20世纪70年代以来美国已禁止使用滴滴涕和多氯联苯，但一些有机氯化合物仍在环境中积累并持续存在。因此，在人体组织中仍然可以发现可测量的量。由于一些有机氯化合物在体外和实验动物系统中起雌激素激动剂或拮抗剂的作用，因此人们假设并研究了有机氯暴露与乳腺癌风险的可能关联。尽管有少数研究支持这一假设，但绝大多数流行病学研究并不支持。虽然其中一些化合物可能对环境或健康产生其他不利影响，但人们认为接触有机氯与乳腺癌没有因果关系，对可能接触有机氯感到关切的妇女可以放心，现有证据并未表明这些化学品与乳腺癌之间存在关联。
Organochlorines are a diverse group of synthetic chemicals that include polychlorinated biphenyls (PCBs), dioxins, and organochlorine pesticides such as dichlorodiphenyl-trichloroethane (DDT), lindane, and hexachlorobenzene. Although use of DDT and PCBs has been banned in the United States since the 1970s, some organochlorine compounds have accumulated and persisted within the environment. As a result, measurable amounts can still be found in human tissue. Because some organochlorine compounds act as estrogen agonists or antagonists within in vitro and experimental animal systems, a possible association of breast cancer risk with organochlorine exposure has been hypothesized and investigated. Although a few studies support this hypothesis, the vast majority of epidemiological studies do not. While some of these compounds may have other adverse environmental or health effects, organochlorine exposure is not believed to be causally related to breast cancer Women concerned about possible organochlorine exposure can be reassured that available evidence does not suggest an association between these chemicals and breast cancer.