Ionic amplifying circuits inspired by electronics and biology
Ionic amplifying circuits inspired by electronics and biology
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DOI：
10.1038/s41467-020-15398-3
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发表时间：
2020-03-26
影响因子：
16.6
通讯作者：
Siwy, Zuzanna S.
中科院分区：
文献类型：
--
作者：
Lucas, Rachel A.;Lin, Chih-Yuan;Siwy, Zuzanna S.
集成电路存在于所有的电子设备中，使信号放大、调制和继电器成为可能。大自然使用另一种由细胞膜上的通道组成的电路来调节和放大离子的传输，而不是电子系统中的电子和空穴。在这里，我们展示了一个灵感来自电子学和生物学概念的非生物离子电路。该电路将小的离子信号放大为离子输出，其工作模拟了由晶体管组成的电子达林顿放大器。单个晶体管是带有三个终端的孔，其中包括一个能够富集或耗尽孔中的离子的栅极。我们报告的电路在小于1V的门电压下工作，响应sub-nA门电流，并提供增益高达300的离子电流放大。离子放大器是改善化学和生化传感、分离和放大等方面的一个合乎逻辑的步骤。
Integrated circuits are present in all electronic devices, and enable signal amplification, modulation, and relay. Nature uses another type of circuits composed of channels in a cell membrane, which regulate and amplify transport of ions, not electrons and holes as is done in electronic systems. Here we show an abiotic ionic circuit that is inspired by concepts from electronics and biology. The circuit amplifies small ionic signals into ionic outputs, and its operation mimics the electronic Darlington amplifier composed of transistors. The individual transistors are pores equipped with three terminals including a gate that is able to enrich or deplete ions in the pore. The circuits we report function at gate voltages < 1V, respond to sub-nA gate currents, and offer ion current amplification with a gain up to 300. Ionic amplifiers are a logical step toward improving chemical and biochemical sensing, separations and amplification, among others.