Bimodal MR-PET agent for quantitative pH imaging.
Bimodal MR-PET agent for quantitative pH imaging.
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DOI：
10.1002/anie.201000075
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发表时间：
2010-03-22
影响因子：
16.6
通讯作者：
Caravan, Peter
中科院分区：
文献类型：
--
作者：
Frullano, Luca;Catana, Ciprian;Benner, Thomas;Sherry, A Dean;Caravan, Peter
可激活或“智能”的磁共振造影剂具有取决于环境因素的松弛能力，如pH或酶活性，但磁共振信号取决于松弛能力和试剂浓度--这两个未知数。双峰方法结合了正电子发射体，解决了这个问题。使用生物模式、pH响应型MR-PET试剂GdDOTA-4AMP-F同时进行正电子发射断层扫描(PET)和磁共振成像，可以直接确定浓度(PET)和T1(MRI)，从而确定pH值。
Activatable or “smart” magnetic resonance contrast agents have relaxivities that depend on environmental factors such as pH or enzymatic activity, but the MR signal depends on relaxivity and agent concentration – two unknowns. A bimodal approach, incorporating a positron emitter, solves this problem. Simultaneous positron emission tomography (PET) and MR imaging with the biomodal, pH-responsive MR-PET agent GdDOTA-4AMP-F allows direct determination of both concentration (PET) and T1 (MRI), and hence pH.