Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation.
Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation.
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DOI：
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发表时间：
2000-06
影响因子：
21.1
通讯作者：
A. Griffioen;G. Molema
中科院分区：
文献类型：
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作者：
A. Griffioen;G. Molema
血管生成，或从预先存在的毛细血管形成新血管，是一系列事件，其对于许多生理和病理过程（诸如癌症、缺血性疾病和慢性炎症）是基本的。随着几种促血管生成分子如血管内皮细胞生长因子、成纤维细胞生长因子（如FGF）和血管生成素的鉴定，以及最近对血管生成的特异性抑制剂如血小板因子-4、血管抑制素、内皮抑制素和血管抑制素的描述，人们认识到，对脉管系统形成的治疗性干扰为各种病理学的临床应用提供了工具。尽管抑制血管生成可以预防具有过度血管生长的疾病，例如癌症、糖尿病视网膜病变和关节炎，但刺激血管生成将有益于治疗疾病，例如冠状动脉疾病和糖尿病中的严重肢体缺血。在这篇综述中，我们强调了目前的知识，血管生成的调控和报告的最新发现，在血管生成的研究和临床研究。我们还讨论了在这一研究领域的潜力，局限性和挑战，在新的治疗策略的发展，其中血管生成起着重要作用的疾病。
Angiogenesis, or the formation of new blood vessels out of pre-existing capillaries, is a sequence of events that is fundamental to many physiologic and pathologic processes such as cancer, ischemic diseases, and chronic inflammation. With the identification of several proangiogenic molecules such as the vascular endothelial cell growth factor, the fibroblast growth factors (like in FGFs), and the angiopoietins, and the recent description of specific inhibitors of angiogenesis such as platelet factor-4, angiostatin, endostatin, and vasostatin, it is recognized that therapeutic interference with vasculature formation offers a tool for clinical applications in various pathologies. Whereas inhibition of angiogenesis can prevent diseases with excessive vessel growth such as cancer, diabetes retinopathy, and arthritis, stimulation of angiogenesis would be beneficial in the treatment of diseases such as coronary artery disease and critical limb ischemia in diabetes. In this review we highlight the current knowledge on angiogenesis regulation and report on the recent findings in angiogenesis research and clinical studies. We also discuss the potentials, limitations, and challenges within this field of research, in light of the development of new therapeutic strategies for diseases in which angiogenesis plays an important role.