Modular Synthesis of Triarylmethanes through Palladium-Catalyzed Sequential Arylation of Methyl Phenyl Sulfone
Modular Synthesis of Triarylmethanes through Palladium-Catalyzed Sequential Arylation of Methyl Phenyl Sulfone
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DOI：
10.1002/anie.201307019
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发表时间：
2014-01-13
影响因子：
16.6
通讯作者：
Crudden, Cathleen M.
中科院分区：
文献类型：
--
作者：
Nambo, Masakazu;Crudden, Cathleen M.
三芳基甲烷是一种在材料、传感和制药等领域具有重要价值的结构，以甲基苯基砜为原料合成了价格低廉、易得的三芳基甲烷。三个芳基通过两个顺序钯催化的C-H芳基化反应安装，然后是芳基化脱硫。该方法为利用现有的卤代芳烃和芳基硼酸合成多取代三芳基甲烷提供了一种新的方法，对制备尚未开发的三芳基甲烷基材料和药物也有价值。
Triarylmethanes, which are valuable structures in materials, sensing and pharmaceuticals, have been synthesized starting from methyl phenyl sulfone as an inexpensive and readily available template. The three aryl groups were installed through two sequential palladium-catalyzed C-H arylation reactions, followed by an arylative desulfonation. This method provides a new synthetic approach to multisubstituted triarylmethanes using readily available haloarenes and aryl boronic acids, and is also valuable for the preparation of unexplored triarylmethane-based materials and pharmaceuticals.