Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
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DOI：
10.1038/nm.4000
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发表时间：
2015-12
期刊：
影响因子：
82.9
通讯作者：
van Deursen JM
中科院分区：
文献类型：
--
作者：
Childs BG;Durik M;Baker DJ;van Deursen JM
细胞衰老，一个过程，施加永久增殖停滞细胞响应于各种压力，已成为一个潜在的重要贡献者老化和年龄相关疾病，它是一个有吸引力的目标，用于治疗开发。在过去的半个世纪中，已经获得了大量关于培养细胞衰老的信息;然而，对活生物体中的衰老知之甚少，主要是因为与组织和器官中衰老细胞的鉴定和表征相关的技术限制。此外，新认识到的衰老的有益信号传导功能表明，不加区别地靶向衰老细胞或调节其分泌组用于抗衰老治疗可能具有负面后果。在这里，我们讨论了当前的进展和挑战，在了解体内诱导衰老的应激源，容易衰老的细胞类型，以及衰老和年龄相关疾病以及疾病治疗的背景下衰老细胞的自分泌和旁分泌特性。
Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging and age-related disease, and it is an attractive target for therapeutic exploitation. A wealth of information about senescence in cultured cells has been acquired over the past half century; however, senescence in living organisms is poorly understood, largely because of technical limitations relating to the identification and characterization of senescent cells in tissues and organs. Furthermore, newly recognized beneficial signaling functions of senescence suggest that indiscriminately targeting senescent cells or modulating their secretome for anti-aging therapy may have negative consequences. Here we discuss current progress and challenges in understanding the stressors that induce senescence in vivo, the cell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in the contexts of aging and age-related diseases as well as disease therapy.