The relative efficacy of fluoxetine and manual-based self-help in the treatment of outpatients with bulimia nervosa
The relative efficacy of fluoxetine and manual-based self-help in the treatment of outpatients with bulimia nervosa
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DOI：
10.1097/00004714-200106000-00008
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发表时间：
2001-06-01
影响因子：
2.9
通讯作者：
Al-Banna, M
中科院分区：
文献类型：
--
作者：
Mitchell, JE;Fletcher, L;Al-Banna, M
进行了一项随机、安慰剂对照研究，检查氟西汀和自助手册对神经性贪食症女性抑制贪食行为的单一和联合作用。共有91名患有神经性贪食症的成年女性被随机分配到四种情况之一：仅安慰剂，仅氟西汀，安慰剂和自助手册，或氟西汀和自助手册。受试者治疗16周。主要结果测量包括暴食行为的自我报告。氟西汀和自助手册被认为是有效的，在减少呕吐发作的频率，并在改善呕吐和暴食发作的反应率。此外，这两个因素被证明是在本研究中的主要和次要疗效措施，结果进行了讨论，与以前的研究和神经性贪食症的治疗的影响。
A randomized, placebo-controlled study was conducted examining the singular and combined effects of fluoxetine and a self-help manual on suppressing bulimic behaviors in women with bulimia nervosa. A total of 91 adult women with bulimia nervosa were randomly assigned to one of four conditions: placebo only, fluoxetine only, placebo and a self-help manual, or fluoxetine and a self-help manual. Subjects were treated for 16 weeks. Primary outcome measures included self-reports of bulimic behaviors. Fluoxetine and a self-help manual were found to be effective in reducing the frequency of vomiting episodes and in improving the response rates for vomiting and binge-eating episodes. Furthermore, both factors were shown to be acting additively on the primary and secondary efficacy measures in this study, Results are discussed in relation to previous research and the implications for treatment of bulimia nervosa.