CD1 RECOGNITION BY MOUSE NK1(+) T-LYMPHOCYTES
CD1 RECOGNITION BY MOUSE NK1(+) T-LYMPHOCYTES
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DOI：
10.1126/science.7538697
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发表时间：
1995-05-12
期刊：
影响因子：
56.9
通讯作者：
BRUTKIEWICZ, RR
中科院分区：
文献类型：
--
作者：
BENDELAC, A;LANTZ, O;BRUTKIEWICZ, RR
罕见的主要组织相容性复合体（MHC）类I-like CD1特异性T细胞已经从人类血液中分离出来，但尚不确定这些克隆是否是在T细胞发育过程中选择的CD1特异性T细胞的一部分，或者它们对CD1的识别是否是偶然的交叉反应。在小鼠中，发现具有独特表型的α - β胸腺细胞的整个亚群是cd1特异性的。这一特定的亚群及其人类对应体提供了证据，证明CD1在选择和与特化的α β T细胞相互作用中具有一般作用。
Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.