Downstream of phosphatidylinositol-3 kinase, a multifunctional signaling molecule, and its regulation in cell responses.
Downstream of phosphatidylinositol-3 kinase, a multifunctional signaling molecule, and its regulation in cell responses.
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磷脂酰肌醇 3 激酶的下游（一种多功能信号分子）及其对细胞反应的调节。
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
Satoshi Nagata
中科院分区：
文献类型：
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作者：
Y. Fukui;S. Ihara;Satoshi Nagata
磷脂酰肌醇-3激酶是一种将磷脂酰肌醇及其衍生物的D-3位磷酸化的酶。它在生长因子或分化因子刺激后立即被激活，提示PI-3激酶参与了刺激的信号转导。PI-3激酶在许多细胞反应中扮演着重要的角色，包括对细胞核的信号传递、囊泡运输和细胞骨架重排，因为PI-3激酶的抑制或激活影响了许多需要这些事件的细胞反应。要了解PI-3激酶是如何以多种方式发挥作用的，重要的是要确定PI-3激酶下游的因素。在这篇综述中，我们讨论了PI-3激酶下游的因素以及用于识别它们的方法。最近的研究表明，一些参与囊泡运输或细胞骨架重排的蛋白质受到PI-3激酶产生的磷脂的调节，这暗示了PI-3激酶调节这些细胞反应的机制。
Phosphatidylinositol (PI)-3 kinase is an enzyme that phosphorylates the D-3 position of PI and its derivatives. It is activated immediately after growth factor or differentiation factor stimulation, suggesting that PI-3 kinase is involved in signal transduction of the stimulation. PI-3 kinase appears to play various important roles including signaling to the nucleus, vesicle transport, and rearrangement of the cytoskeleton since many cell responses which require these events are affected by inhibition or activation of PI-3 kinase. To understand how PI-3 kinase can act in such multiple ways, it is important to identify the factors downstream of PI-3 kinase. In this review, we discuss the factors downstream of PI-3 kinase and the methods used to identify them. Recent studies revealed that some proteins involved in vesicle transport or in rearrangement of the cytoskeleton are regulated by the phospholipids generated by PI-3 kinase, implying the mechanism by which PI-3 kinase regulates these cell responses.