Cell type specification during sea urchin development.
Cell type specification during sea urchin development.
复制标题
海胆发育过程中的细胞类型规范。
DOI：
10.1016/0168-9525(91)90367-y
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Davidson,EH
中科院分区：
文献类型：
--
作者：
Cameron,RA;Davidson,EH
最近的发现表明，细胞谱系和命运在海胆发育过程中建立空间限制基因表达中起着关键作用。独特的创始人细胞组通过完整切割的不变模式产生五个基因表达区域。细胞谱系分析表明，第二个胚胎轴，口-背口轴，指定参考第一卵裂平面。在未受干扰的胚胎中，对一个或另一个区域有贡献的克隆开始出现在第三次卵裂时，而建立者细胞向所有五个区域的分离在第六次卵裂时完成。方正细胞分离是建立海胆胚胎发生的空间定义的基因活性的机制的一个关键特征。
Recent discoveries indicate that cell lineages and fates play a key role in the establishment of spatially restricted gene expression during sea urchin development. Unique sets of founder cells generate five territories of gene expression by means of an invariant pattern of complete cleavage. Cell lineage analysis demonstrates that the second embryonic axis, the oral-aboral axis, is specified with reference to the first cleavage plane. In the undisturbed embryo, clones that contribute to one territory or another begin to appear at the third cleavage, and founder cell segregation to all five territories is completed by the sixth cleavage. Founder cell segregation is a key feature of mechanisms that establish the spatially defined gene activity of sea urchin embryogenesis.