Sensitivity of monosynaptic test reflexes to facilitation and inhibition as a function of the test reflex size: a study in man and the cat
Sensitivity of monosynaptic test reflexes to facilitation and inhibition as a function of the test reflex size: a study in man and the cat
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单突触测试反射对促进和抑制的敏感性作为测试反射大小的函数：一项针对人和猫的研究
DOI：
10.1007/bf00230098
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发表时间：
2004
影响因子：
2
通讯作者：
E. Pierrot‐Deseilligny
中科院分区：
文献类型：
--
作者：
C. Crone;H. Hultborn;L. Mazières;C. Morin;J. Nielsen;E. Pierrot‐Deseilligny
摘要在人类和猫的平行实验中，研究了单突触测试反射对促进和抑制的敏感性如何随着对照测试反射本身的大小而变化。在人类中，单突触反射（霍夫曼反射）是在比目鱼肌（通过刺激胫神经）或股四头肌（通过刺激股神经）中引起的。在去大脑猫中，记录了从神经到比目鱼肌和腓肠肌内侧的单突触反射；它们是通过刺激切片的 L7 和 S1 背根的近端而引起的。使用各种兴奋性和抑制性脊髓反射途径来调节测试反射（例如单突触 Ia 兴奋、双突触相互抑制、皮肤抑制、反复抑制、介导测试反射的 Ia 纤维的突触前抑制）。结果表明，通过恒定的兴奋性条件刺激在单突触测试反射中招募的运动神经元的额外数量很大程度上取决于测试反射本身的大小。无论条件刺激如何，这种依赖性都具有相同的特征模式。随着测试反射大小的增加，额外招募的运动神经元的数量首先增加，然后达到峰值（或平台），最后减少。抑制性条件刺激也存在类似的关系。讨论了导致这些发现的基本生理因素。最后，考虑了用 H 反射技术解释人体实验的意义。
SummaryIn parallel experiments on humans and in the cat it was investigated how the sensitivity of monosynaptic test reflexes to facilitation and inhibition varies as a function of the size of the control test reflex itself. In man the monosynaptic reflex (the Hoffmann reflex) was evoked in either the soleus muscle (by stimulation of the tibial nerve) or the quadriceps muscle (by stimulation of the femoral nerve). In the decerebrate cat monosynaptic reflexes were recorded from the nerves to soleus and medial gastrocnemius muscles; they were evoked by stimulation of the proximal ends of the sectioned L7 and S1 dorsal roots. Various excitatory and inhibitory spinal reflex pathways were used for conditioning the test reflexes (e.g. monosynaptic Ia excitation, disynaptic reciprocal inhibition, cutaneous inhibition, recurrent inhibition, presynaptic inhibition of the Ia fibres mediating the test reflex). It was shown that the additional number of motoneurones recruited in a monosynaptic test reflex by a constant excitatory conditioning stimulus was very much dependent on the size of the test reflex itself. This dependency had the same characteristic pattern whatever the conditioning stimulus. With increasing size of the test reflex the number of additionally recruited motoneurones first increased, then reached a peak (or plateau) and finally decreased. A similar relation was also seen with inhibitory conditioning stimuli. The basic physiological factors responsible for these findings are discussed. Finally, the implications for the interpretation of experiments in man with the H-reflex technique are considered.