Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles.
Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles.
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DOI：
10.1530/rep-11-0114
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Moley KH
中科院分区：
文献类型：
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作者：
Frolova AI;Moley KH
促进性葡萄糖转运分子（葡萄糖转运体，GLUTs）负责葡萄糖跨细胞膜转运。在14个家族成员中，有9个在小鼠子宫中表达，7个在人类子宫中表达。一些研究表明，充足的葡萄糖摄取和代谢对于子宫内膜向能够支持胚胎着床的接受状态的适当分化是必不可少的。然而，GLUTs在子宫内膜功能中的机制作用仍然知之甚少。本文旨在介绍目前关于GLUT在子宫中的表达及其在子宫内膜不同细胞类型中的分布的知识。此外，它分析了GLUTs在正常子宫生理以及不孕症、子宫内膜癌和多囊卵巢综合征的病理状况中可能发挥的作用的现有数据。
Facilitative glucose transport molecules (glucose transporters, GLUTs) are responsible for glucose transport across cellular membranes. Of the 14 family members, expression of nine has been reported in the murine uterus and seven in the human uterus. Some studies reveal that adequate glucose uptake and metabolism are essential for the proper differentiation of the uterine endometrium toward a receptive state capable of supporting embryo implantation. However, the mechanistic role of GLUTs in endometrial function remains poorly understood. This review aims to present the current knowledge about GLUT expression in the uterus and distribution among the different cell types within the endometrium. In addition, it analyzes the available data in the context of roles GLUTs may play in normal uterine physiology as well as the pathological conditions of infertility, endometrial cancer, and polycystic ovarian syndrome.