Association between change in bone mineral density and decline in usual walking speed in elderly community-dwelling japanese women during 2 years of follow-up
Association between change in bone mineral density and decline in usual walking speed in elderly community-dwelling japanese women during 2 years of follow-up
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DOI：
10.1111/j.1532-5415.2007.01066.x
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发表时间：
2007-02-01
影响因子：
6.3
通讯作者：
Furuna, Taketo
中科院分区：
文献类型：
--
作者：
Kwon, Jinhee;Suzuki, Takao;Furuna, Taketo
目的：研究在2年的随访中，老年社区生活的日本妇女的骨密度（BMD）变化与日常步行速度变化之间的关系。设计：纵向队列研究。设置：以社区为基础。参与者：共有182名年龄在70至84岁之间的妇女完成了基线调查和2年后的随访调查。测量：在基线和2年后随访时进行访谈、人体测量、血液分析和体能测试。采用双能X线骨密度仪测量前臂骨密度。计算2年随访期间BMD和通常步行速度的年度百分比变化;以四分位数总结BMD的年度百分比变化。每年的骨丢失率和通常的步行速度下降之间的关联进行了分析，采用多元线性回归调整的变化，肌肉力量，平衡能力，和其他潜在的confronters.Results：骨密度的变化显着相关的变化，通常的步行速度在2年的后续行动。经多变量校正后，BMD下降的老年女性的日常步行速度下降更明显（在BMD百分比变化的第一个四分位数中步行速度变化为-3.5%，在第二个四分位数中为-3.1%）（第四个四分位数为+1.5%）。即使在对潜在混杂因素进行多变量校正后，骨密度降低的老年妇女的日常步行速度也比骨密度增加的妇女下降得更明显。
OBJECTIVES: To investigate the association between change in bone mineral density (BMD) and change in usual walking speed in elderly community-living Japanese women during 2 years of follow-up.DESIGN: Longitudinal cohort study.SETTING: Community-based.PARTCIPANTS: A total of 182 women aged 70 to 84 who completed a baseline survey and a follow-up survey 2 years later.MEASUREMENTS: An interview, anthropometric measurements, blood analysis, and physical performance tests were performed at baseline and at follow-up 2 years later. BMD was evaluated using dual-energy X-ray absorptiometry measured at the forearm. Annual percentage changes in BMD and usual walking speed during the 2-year follow-up period were calculated; annual percentage changes in BMD were summarized in quartiles. The association between annual bone loss rate and decline in usual walking speed was analyzed using multiple linear regression adjusted for changes in muscle strength, balance capability, and other potential confounders.RESULTS: Change in BMD was significantly related to change in usual walking speed during the 2-year follow-up. After multivariate adjustment, usual walking speed declined significantly more in elderly women whose BMD decreased (-3.5% change in walking speed in the first quartile of percentage change in BMD and -3.1% in the second quartile) than in women whose BMD increased (+1.5% in fourth quartile).CONCLUSION: Elderly women whose BMD decreased had a significantly greater decline in usual walking speed than women whose BMD increased, even after multivariate adjustment of potential confounders.