Racial disparities of pancreatic cancer in Georgia: a county-wide comparison of incidence and mortality acrossthe state, 2000-2011
Racial disparities of pancreatic cancer in Georgia: a county-wide comparison of incidence and mortality acrossthe state, 2000-2011
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DOI：
10.1002/cam4.552
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发表时间：
2016-01-01
期刊：
影响因子：
4
通讯作者：
Robb, Sara W.
中科院分区：
文献类型：
--
作者：
Brotherton, Lindsay;Welton, Michael;Robb, Sara W.
了解胰腺癌的地理分布对于评估疾病负担和识别高危人群非常重要。本研究调查了格鲁吉亚胰腺癌发病率、死亡率和死亡率与发病率比（MIRs）的地理趋势，特别关注疾病的种族差异。获得了2000-2011年格鲁吉亚县（N=159）的直接年龄校正胰腺癌发病率和死亡率。非裔美国人和高加索人的县年龄调整疾病率和MIRs地图分别生成。进行聚类分析，以确定癌症病例或死亡的不寻常的地理聚集。计算皮尔逊相关系数以检查县健康因素之间的关联（例如，健康行为、临床护理和物理环境）和胰腺癌发病率或死亡率。与白人相比，非裔美国人的年龄校正发病率（14.6/100，000）和死亡率（13.3/100，000）显著更高。聚类分析确定了五个显着的发病率集群和四个显着的死亡率集群中的高加索人，一个显着的发病率集群和两个显着的死亡率集群中确定的非洲裔美国人。在非裔美国人中，物理环境与胰腺癌发病率（=0.16，P=0.04）和死亡率（=0.18，P=0.02）之间存在微弱但显著的相关性。在格鲁吉亚的非裔美国人中，胰腺癌发病率和死亡率的负担不成比例。疾病干预工作应在高风险地区实施，如西南部和中部地区。未来的研究应评估健康行为和物理环境与胰腺癌空间分布的关系。
Understanding the geographic distribution of pancreatic cancer is important in assessing disease burden and identifying high-risk populations. This study examined the geographic trends of pancreatic cancer incidence, mortality, and mortality-to-incidence ratios (MIRs) in Georgia, with a special focus on racial disparities of disease. Directly age-adjusted pancreatic cancer incidence and mortality rates for Georgia counties (N=159) were obtained for 2000-2011. Maps of county age-adjusted disease rates and MIRs were generated separately for African Americans and Caucasians. Cluster analyses were conducted to identify unusual geographic aggregations of cancer cases or deaths. Pearson correlation coefficients were calculated to examine associations between county health factors (e.g., health behaviors, clinical care, and physical environment) and pancreatic cancer incidence or mortality rates. African Americans displayed a significantly higher age-adjusted incidence (14.6/100,000) and mortality rate (13.3/100,000), compared to Caucasians. Cluster analyses identified five significant incidence clusters and four significant mortality clusters among Caucasians; one significant incidence cluster and two significant mortality clusters were identified among African Americans. Weak but significant correlations were noted between physical environment and pancreatic cancer incidence (=0.16, P=0.04) and mortality (=0.18, P=0.02) among African Americans. A disproportion burden of pancreatic cancer incidence and mortality was exhibited among African Americans in Georgia. Disease intervention efforts should be implemented in high-risk areas, such as the southwest and central region of the state. Future studies should assess health behaviors and physical environment in relationship with the spatial distribution of pancreatic cancer.