Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas
Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas
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DOI：
10.3892/or_00000706
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发表时间：
2010-03-01
期刊：
影响因子：
4.2
通讯作者：
Moriuchi, Tetsuya
中科院分区：
文献类型：
--
作者：
Kanai, Motoshi;Hamada, Jun-Ichi;Moriuchi, Tetsuya
HOX基因是胚胎发生过程中赋予细胞位置信息的主要调控基因。在本研究中，我们比较了39个HOX基因在人类右大肠前（盲肠、升结肠和横结肠）、左大肠前（降结肠、乙状结肠和直肠）和肝细胞癌中的表达模式。real-time RT-PCR分析各HOX基因的表达水平。HOX基因在结直肠癌和肝细胞癌组织中的表达模式与正常或非癌组织中的表达模式不同。在大肠右侧肿瘤组织和左侧肿瘤组织之间。不同的HOX基因表达与癌症相关。此外，HOXD8在结直肠癌肝转移组织中的表达水平与非癌性肝组织一样低，且显著低于原发组织。这些结果表明，HOX基因的表达失调在结直肠癌和肝细胞癌的发生和恶性进展中起重要作用。
HOX genes are known its master regulator genes which give cells positional information in embryogenesis. In this Study, we compared the expression patterns of 39 HOX genes among human colorectal carcinomas front the right large intestine (cecum, ascending and transverse colon), those from the left large intestine (discending and sigmoid colon, and rectum) and hepatocellular carcinoma. The expression levels of each HOX gene were quantified by analysis based on the real-time RT-PCR. The expression patterns of HOX genes in colorectal and hepatocellular carcinoma tissues differed from those in their normal or non-cancerous tissues. Between the tumor tissues in the right-side large intestine and those in the left-side. different HOX genes were expressed in association with cancer. Further, the expression levels of HOXD8 in liver-metastatic tissues of colorectal carcinomas were as low as in non-cancerous liver tissues, and were significantly lower than those in the primary tissues. These results suggest that dysregulated expressions of HOX genes play all important role in carcinogenesis and malignant progression of colorectal and hepatocellular carcinomas.