Physiological levels of melatonin contribute to the antioxidant capacity of human serum
Physiological levels of melatonin contribute to the antioxidant capacity of human serum
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DOI：
10.1111/j.1600-079x.1999.tb00597.x
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发表时间：
1999-08-01
影响因子：
10.3
通讯作者：
Guerrero, JM
中科院分区：
文献类型：
--
作者：
Benot, S;Goberna, R;Guerrero, JM
这项工作评估了松果体分泌产物褪黑激素的生理浓度是否有助于人血清的总抗氧化状态（TAS）。从 2 岁至 89 岁的健康志愿者中采集白天和夜间血清样本，用于测量褪黑激素和 TAS。结果显示，人血清中的褪黑激素和 TAS 均表现出 24 小时变化，夜间峰值出现在 01:00 小时。此外，志愿者在夜间接受光照会导致 TAS 和褪黑激素明显下降。此外，当从夜间收集的血清中去除褪黑激素时，样品的 TAS 值降低至白天的基础值。在衰老研究中，发现TAS和褪黑激素的夜间血清值在前四十年表现出最大值；此后，这些值随着年龄的增长而下降。在 60 岁的个体中，血清褪黑激素和 TAS 水平的昼夜差异明显减小，减少了 80% 以上，而在老年个体中，这些差异完全消失。我们的结果表明褪黑激素有助于人血清的总抗氧化能力。随着年龄的增长，褪黑激素的抗氧化作用会减少，这与年龄相关的褪黑激素的减少有关。
This work evaluates whether physiological concentrations of the pineal secretory product melatonin contribute to the total antioxidant status (TAS) of human serum. Day and nighttime serum samples were collected from healthy volunteers ranging from 2 to 89 years of age and used to measure melatonin and TAS. Results showed that both melatonin and TAS in human serum exhibited 24 hr variations with nocturnal peak values at 01:00 hr. Moreover, exposure of volunteers to light at night resulted in clear decreases of both TAS and melatonin. Furthermore, when melatonin was removed from sera collected at night, the TAS value of the sample was reduced to basal daytime values. In aging studies, it was found that nocturnal serum values of TAS and melatonin exhibited maximal values during the first four decades; thereafter, these values decreased as age advanced. In 60-year-old individuals, day/night differences in serum melatonin and TAS levels were clearly diminished, by more than 80%, with these differences being completely abolished in older individuals. Our results suggest that melatonin contributes to the total antioxidative capability of human serum. This antioxidant contribution of melatonin is reduced as age advances correlating with the age-related reduction of melatonin.