Biomimetic mineralization of electrospun poly(lactic-co-glycolic acid)/multi-walled carbon nanotubes composite scaffolds in vitro
Biomimetic mineralization of electrospun poly(lactic-co-glycolic acid)/multi-walled carbon nanotubes composite scaffolds in vitro
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DOI：
10.1016/j.matlet.2009.07.061
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发表时间：
2009-11
影响因子：
3
通讯作者：
Hualin Zhang;Jinsong Liu;Zhiwen Yao;Jun Yang;Lingzhan Pan;Zhi-qing Chen
中科院分区：
文献类型：
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作者：
Hualin Zhang;Jinsong Liu;Zhiwen Yao;Jun Yang;Lingzhan Pan;Zhi-qing Chen
仿生矿化是提高某些材料生物相容性和骨诱导性的有效方法。本研究采用静电纺丝法制备了聚乳酸-羟基乙酸（PLGA）和多壁碳纳米管（MWNTs）复合支架。随后，将支架浸泡在37°C的模拟体液（1.5×SBF）中7、14和21天进行仿生矿化。扫描电镜，拉曼光谱和x射线衍射进行表征。结果表明，电纺丝支架的结构形态与天然细胞外基质极为相似。矿化后，磷灰石晶体沉积在PLGA/MWNTs复合支架上。矿化PLGA/MWNTs复合材料可能在组织工程应用中具有潜在的用途，特别是作为骨组织再生的支架。
Biomimetic mineralization is an effective method to improve the biocompatibility and bone inductivity of certain materials. In this study, composite scaffolds composed of poly(lactic-co-glycolic acid) (PLGA) and multi-walled carbon nanotubes (MWNTs) were prepared by electrospinning. Subsequently, the scaffolds were immersed in a simulated body fluid (1.5×SBF) at 37 °C for 7, 14 and 21 days for biomimetic mineralization. Scanning electron microscopy, Raman spectroscopy, and X-ray diffraction were used for characterization. It was found that the electrospun scaffolds had extremely resemblant structural morphology to the natural extracellular matrix. After mineralization, apatite crystals were deposited on the PLGA/MWNTs composite scaffolds. The mineralized PLGA/MWNTs composites may be potentially useful in tissue engineering applications, particularly as scaffolds for bone tissue regeneration.