Estimation of proton density fat fraction of the salivary gland
Estimation of proton density fat fraction of the salivary gland
复制标题
DOI：
10.1259/bjr.20170671
复制
发表时间：
2018-01-01
影响因子：
2.6
通讯作者：
Yoshiura, Kazunori
中科院分区：
文献类型：
--
作者：
Chikui, Toru;Yamashita, Yasuo;Yoshiura, Kazunori
目的：我们的第一个目的是证明六点Dixon法估计唾液腺质子密度脂肪分数（PDFF）的有效性。第二个目的是用Dixon法估计唾液腺PDFF以评估病理情况。方法：首先对12名志愿者进行单体素磁共振波谱法和Dixon法两种测序，比较两种方法得到的pdff。接下来，共67人[正常，n = 46；干燥综合征（SS）， n = 11；和igg4相关泪腺炎和涎腺炎（IgG4-DS）， n = 4，腮腺炎，n = 6]，采用Dixon法估计腮腺（PG）和下颌下腺（SMG）的PDFF。结果：两种方法具有良好的相关性（R-2 = 0.964，斜率= 105）。正常组PG-PDFF与体重、体质指数（BMI）相关（p = 0.38, p = 0.0085; p = 0.63, p < 0.0001）。SMG-PDFF还与体重、BMI和血清甘油三酯相关（p = 0.37, p = 0.0067; p = 0.42, p = 0.0022; p = 0.35, p = 0.024）。SS组的PG-PDFF（48.2 +/- 15.1%）高于其他各组；但由于重叠较大，未发现显著差异。SS组（39.0 +/- 26.14%）的SMG-PDFF也显著高于正常组（8.9 +/- 5.4%,p < 0.0001）和IgG4-DS组（3.8 +/- 2.3%,p = 0.020）。结论：Dixon法是一种可行的估计脂肪堆积的方法，可以显示SS组SMG的脂肪堆积情况。知识进展：Dixon法获得的PDFF有助于了解唾液腺病理状况。
Objective: Our first objective was to prove the validity of the six-point Dixon method for estimating the proton density fat fraction (PDFF) of the salivary gland. The second objective was to estimate the salivary gland PDFF using Dixon method to evaluate the pathological conditions.Methods: At first, 12 volunteers underwent two types of sequences: single-voxel magnetic resonance spectroscopy and the Dixon method and the PDFFs obtained by the two methods were compared. Next, a total of 67 individuals [normal, n = 46; Sjogren's syndrome (SS), n = 11; and IgG4-related dacryoadenitis and sialadenitis (IgG4-DS), n = 4, parotitis, n = 6] were enrolled to estimate the parotid gland (PG) and submandibular gland (SMG) PDFF using the Dixon method.Results: This volunteer study demonstrated excellent correlation between two methods (R-2 = 0.964, slope = 105). In the normal group, the PG-PDFF was correlated with the weight and body mass index (BMI) (p = 0.38, p = 0.0085; and p = 0.63, p < 0.0001). The SMG-PDFF was also correlated with the weight, BMI, and serum triglyceride (p = 0.37, p = 0.0067; p = 0.42, p = 0.0022; and p = 0.35, p = 0.024). The PG-PDFF of the SS group (48.2 +/- 15.1%) was higher than that of any other groups; however, no significant difference was found due to the wide overlap. The SS group (39.0 +/- 26.14%) also had significantly higher SMG-PDFF than the normal group (8.9 +/- 5.4%), p < 0.0001) and IgG4-DS group (3.8 +/- 2.3%), p = 0.020).Conclusion: The Dixon method is a feasible method for estimating the PDFF and demonstrates fat accumulation in SMG in the SS group.Advances in knowledge: The PDFF obtained by the Dixon method is helpful for understanding the salivary gland pathological condition.