RNA STRAND: the RNA secondary structure and statistical analysis database.
RNA STRAND: the RNA secondary structure and statistical analysis database.
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DOI：
10.1186/1471-2105-9-340
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发表时间：
2008-08-13
影响因子：
3
通讯作者：
Condon A
中科院分区：
文献类型：
--
作者：
Andronescu M;Bereg V;Hoos HH;Condon A
获取、搜索和分析大量已知RNA分子的二级结构的能力对于获得改进的RNA能量模型、评估RNA二级结构的计算预测以及更好地理解RNA折叠是非常重要的。目前还没有一个数据库可以很容易地为几乎所有已知二级结构的RNA分子提供这些功能。在本文中，我们描述了RNA链-RNA二级结构和统计分析数据库，一个包含任何类型和生物体的已知二级结构的策划数据库。我们的新数据库提供了一个广泛的收集已知的RNA二级结构从公共数据库，搜索和下载的一个共同的格式。我们的数据库中的二级结构的综合统计信息是使用RNA二级结构分析仪提供的，这是我们开发的一种分析RNA二级结构的新工具。由此获得的信息对于理解某些结构基序出现的程度和概率是有价值的。我们概述了几种方法，在RNA链中提供的数据可以促进RNA结构的研究，包括RNA能量模型的改进和二级结构预测程序的评估。为了与新的RNA二级结构实验保持同步，我们提供了必要的工具来将解决的RNA二级结构添加到我们的数据库中，并邀请研究人员为RNA STRAND做出贡献。RNA STRAND是一个精心组装的可信RNA二级结构数据库，具有简单的在线工具，用于搜索，分析和下载用户选择的条目，并可在。
The ability to access, search and analyse secondary structures of a large set of known RNA molecules is very important for deriving improved RNA energy models, for evaluating computational predictions of RNA secondary structures and for a better understanding of RNA folding. Currently there is no database that can easily provide these capabilities for almost all RNA molecules with known secondary structures. In this paper we describe RNA STRAND – the RNA secondary STRucture and statistical ANalysis Database, a curated database containing known secondary structures of any type and organism. Our new database provides a wide collection of known RNA secondary structures drawn from public databases, searchable and downloadable in a common format. Comprehensive statistical information on the secondary structures in our database is provided using the RNA Secondary Structure Analyser, a new tool we have developed to analyse RNA secondary structures. The information thus obtained is valuable for understanding to which extent and with which probability certain structural motifs can appear. We outline several ways in which the data provided in RNA STRAND can facilitate research on RNA structure, including the improvement of RNA energy models and evaluation of secondary structure prediction programs. In order to keep up-to-date with new RNA secondary structure experiments, we offer the necessary tools to add solved RNA secondary structures to our database and invite researchers to contribute to RNA STRAND. RNA STRAND is a carefully assembled database of trusted RNA secondary structures, with easy on-line tools for searching, analyzing and downloading user selected entries, and is publicly available at .
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影响因子：
5.6
作者：
Andronescu, M;Zhang, ZC;Condon, A
通讯作者：
Condon, A
影响因子：
14.9
作者：
Nagaswamy, U;Larios-Sanz, M;Fox, GE
通讯作者：
Fox, GE
影响因子：
5.8
作者：
Andronescu, Mirela;Condon, Anne;Murphy, Kevin P.
通讯作者：
Murphy, Kevin P.
影响因子：
3.4
作者：
BERMAN, HM;OLSON, WK;SCHNEIDER, B
通讯作者：
SCHNEIDER, B
影响因子：
3
作者：
Dirks, RM;Pierce, NA
通讯作者：
Pierce, NA