RELATION OF THE COURSE OF BRONCHIAL RESPONSIVENESS FROM AGE-9 TO AGE-15 TO ALLERGY
RELATION OF THE COURSE OF BRONCHIAL RESPONSIVENESS FROM AGE-9 TO AGE-15 TO ALLERGY
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DOI：
10.1164/ajrccm.152.4.7551386
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发表时间：
1995-10-01
影响因子：
24.7
通讯作者：
SILVA, PA
中科院分区：
文献类型：
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作者：
BURROWS, B;SEARS, MR;SILVA, PA
对9岁、11岁、13岁和15岁的新西兰儿童的出生队列中对乙酰甲胆碱的支气管反应性进行了测量。总体的支气管高反应性(BHR)随着年龄的增长而下降。虽然9岁时的反应与15岁时的反应性、症状严重程度和低肺功能显著相关，但当考虑到9岁后的支气管反应水平时，这些关系要密切得多。此外，在15岁时对乙酰胆碱无反应的儿童中，那些有BHR史的儿童比那些以前的测试完全无反应的儿童有更频繁的喘息和更低的肺功能。BHR的总体倾向和保留BHR的倾向都与高血清IgE水平(在11岁时确定)和过敏皮肤试验阳性(在13岁时确定)密切相关。这些过敏的证据与乙酰甲胆碱反应的严重程度和病程密切相关，似乎是随访结束时喘鸣频率和肺功能损害程度的重要决定因素。考虑到BHR的变异性，在任意时间点对支气管反应性的单一评估可能不是BHR总体趋势的准确指标。
Bronchial responsiveness to methacholine was measured in a birth cohort of New Zealand children at ages 9, 11, 13, and 15. Overall bronchial hyperresponsiveness (BHR) decreased with age. While the response at age 9 was significantly related to responsiveness, symptom severity, and low lung function at age 15, these relationships were much closer when bronchial response levels after age 9 were taken into account. Also, among children who were unresponsive to methacholine at age 15, those with previous BHR had more frequent wheeze and lower lung function than those whose previous tests were ail unresponsive. Both the overall tendency to BHR and the tendency to retain BHR were closely related to high serum IgE levels (determined at age 11) and to positive allergy skin tests (determined at age 13). These evidences of allergy, closely related to the severity and course of methacholine response, appeared to be important determinants of the frequency of wheeze and the degree of impairment of lung function at the end of follow-up. In view of the variability in BHR, a single estimate of bronchial responsiveness taken at an arbitrary point in time may not be an accurate index of the overall tendency to BHR.