Interleukin 1beta induces expression of human herpesvirus 8 encoded genes in BCBL-1 cells.
Interleukin 1beta induces expression of human herpesvirus 8 encoded genes in BCBL-1 cells.
复制标题
白介素 1β 诱导 BCBL-1 细胞中人类疱疹病毒 8 编码基因的表达。
DOI：
10.1097/00002030-199910220-00028
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Offermann,MK
中科院分区：
文献类型：
--
作者：
Yu,Y;Roan,F;Offermann,MK
卡波西肉瘤（KS）是一种多灶性肿瘤，是感染HIV-1的患者中最常见的肿瘤，但也见于一些HIV阴性个体[1-3]。人类疱疹病毒8型（HHV 8）几乎存在于所有KS病变中，与KS风险组无关，表明HHV 8是一种必要的病毒病原体[4-7]。血清学研究表明，HHV 8感染通常先于KS临床发展数年[8]。此外，并非所有感染HHV 8的个体都会发生KS [9-11]。因此，除了HHV 8感染外，可能还有宿主因素有助于KS的临床发展。
Kaposi ‚s sarcoma (KS) is a multifocal neoplasm that is the most common neoplasm in patients infected with HIV-1 but is also found in some HIV-negative individuals [1-3]. Human herpesvirus 8 (HHV8) is found in virtually all KS lesions irrespective of the risk group for KS, suggesting that HHV8 is a necessary viral pathogen [4-7]. Serological studies suggest that infection with HHV8 often precedes the clinical development of KS by years [8]. Furthermore, not all individuals infected with HHV8 develop KS [9-11]. There are therefore likely to be host factors in addition to infection with HHV8 that contribute to the clinical development of KS.