Astroglia and glutamate in physiology and pathology: aspects on glutamate transport, glutamate-induced cell swelling and gap-junction communication
Astroglia and glutamate in physiology and pathology: aspects on glutamate transport, glutamate-induced cell swelling and gap-junction communication
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DOI：
10.1016/s0197-0186(00)00033-4
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发表时间：
2000-08-01
影响因子：
4.2
通讯作者：
Rönnbäck, L
中科院分区：
文献类型：
--
作者：
Hansson, E;Muyderman, H;Rönnbäck, L
星形胶质细胞具有监测细胞外谷氨酸(Glu)的能力，并将其维持在低水平，代谢Glu，或将其释放回细胞外空间。谷氨酸可以诱导星形胶质细胞体积增加，导致细胞外空间减少，从而改变细胞外物质的浓度。许多证据表明，K+可以在星形胶质细胞缝隙连接耦合网络中被缓冲。最近的结果表明，同性恋连接对Glu是可渗透的。所有这些事件都是动态发生的：星形胶质细胞网络具有主动干扰神经传递的能力，从而为Gln传递提供了高信噪比。然后，在正常生理过程中可以保持高质量的神经元信息。在相同的机制下，星形胶质细胞可能在细胞外Glu浓度适度升高的情况下发挥神经保护作用，即对应于病理性高兴奋性条件，或对应于急性脑损伤的早期阶段。如果星形胶质功能衰竭，神经元功能障碍可能会得到加强。(C)2000爱思唯尔科学有限公司。保留所有权利。
Astroglia have the capacity to monitor extracellular glutamate (Glu) and maintain it at low levels, metabolize Glu, or release it back into the extracellular space. Glu can induce an increase in astroglial cell volume with a resulting decrease of the extracellular space, and thereby alter the concentration of extracellular substances. Many lines of evidence show that K+ can be buffered within the astroglial gap-junction-coupled network. and recent results show that gay junctions are permeable for Glu. All these events occur dynamically: the astroglial network has the capacity to interfere actively with neurotransmission, thereby contributing to a high signal-to-noise ratio for the Gln transmission. High-quality neuronal messages during normal physiology can then be maintained. With the same mechanisms, astroglia might exert a neuroprotective function in situations of moderately increased extracellular Glu concentrations, i.e,, corresponding to conditions of pathological hyper-excitability, or corresponding to early stages of an acute brain injury. If the astroglial functions are failing, neuronal dysfunction can be reinforced. (C) 2000 Elsevier Science Ltd. All rights reserved.