Cognitive neuroepigenetics: a role for epigenetic mechanisms in learning and memory.
Cognitive neuroepigenetics: a role for epigenetic mechanisms in learning and memory.
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DOI：
10.1016/j.nlm.2010.12.008
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发表时间：
2011-07
影响因子：
2.7
通讯作者：
Sweatt, J David
中科院分区：
文献类型：
--
作者：
Day, Jeremy J;Sweatt, J David
尽管长久的行为记忆一直被认为需要同样持久的分子变化，但人们对记忆储存和维持的生化基础知之甚少。越来越多的证据表明，长期的行为改变可能与中枢神经系统转录的表观遗传调控有关。在这篇综述中，我们提出证据表明DNA甲基化的变化有助于记忆的形成和维持，考虑DNA甲基化如何影响记忆相关基因的读出，并讨论这些变化在记忆回路的大范围背景下是如何重要的。最后，我们讨论了研究大脑表观遗传变化所涉及的潜在挑战，并强调了表观遗传机制如何与其他认知过程相关。
Although long-lasting behavioral memories have long been thought to require equally persistent molecular changes, little is known about the biochemical underpinnings of memory storage and maintenance. Increasing evidence now suggests that long-term behavioral change may be associated with epigenetic regulation of transcription in the central nervous system. In this review, we present evidence that changes in DNA methylation contribute to memory formation and maintenance, consider how DNA methylation affects readout of memory-related genes, and discuss how these changes may be important in the large-scale context of memory circuits. Finally, we discuss potential challenges involved in examining epigenetic changes in the brain and highlight how epigenetic mechanisms may be relevant for other cognitive processes.