Histologic and histomorphometric evaluation of the bone regeneration following cortical bone repositioning in a rabbit mandible.
Histologic and histomorphometric evaluation of the bone regeneration following cortical bone repositioning in a rabbit mandible.
复制标题
兔下颌骨皮质骨重新定位后骨再生的组织学和组织形态学评估。
DOI：
10.1111/cid.12777
复制
发表时间：
2019
影响因子：
3.6
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Martinez-de la Cruz G;Yamauchi K;Odajima K;Kataoka Y;Nogami S;Takahashi T
背景虽然骨移植（BG）是骨增量的金标准，目的评价自体骨块移植后骨形成的能力，并探讨其在骨缺损修复中的作用（术后2、5和8周）。从下颌骨体中取出皮质块，将一半皮质块定位并固定在缺损旁的原始骨表面上，另一半皮质块仅保持在缺损上方。确定了三个区域用于评价：BG、CBR和缺损（D）区域。区域进行了评估micro-CT，组织学，histomorphometric analysis.ResultsThere是BG和CBR之间的距离和面积在组织形态计量学分析的评价无统计学差异（P<0.05）。第2周D面积与BG和CBR相比有统计学意义的降低。组织学观察，第2周新生骨明显，第8周三个区域均可见成熟骨，D区消失，与升高的骨块完全融合。结论CBR具有骨增量的潜力，可作为BG诱导的愈合过程的再生能力。
BackgroundAlthough bone graft (BG) is the gold standard for bone augmentation, its use is hampered by donor site morbidity and limited quantity.PurposeTo evaluate the capabilities of bone formation by cortical bone repositioning (CBR) as the healing response following grafting of autogenous bone block without filling biomaterial at the gap between gap and recipient.Materials and MethodsTwelve Japanese White rabbits were divided into three groups (postoperative 2, 5, and 8 weeks). A cortical block was freed from the mandibular body, half of the block was positioned and fixed overlapped the original bone surface beside the defect and the other half remained only elevated above the defect. Three areas were decided for the evaluation; BG, CBR, and defect (D) area. Areas were evaluated by micro‐CT, histology, and histomorphometric analysis.ResultsThere is no statistical difference between BG and CBR by evaluating distance and area in histomorphometrical analysis (P< .05). D area showed statistical decrease compared with BG and CBR at week 2. Histologically, new bone was evident at week 2, mature bone was observed in all three areas at week 8, D area disappeared and fused completely with the elevated bone block.ConclusionCBR has potential for bone augmentation as BG induced from its own regenerative ability of healing process.
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DOI：
10.1016/s0901-5027(87)80125-x
发表时间：
1987-04-01
影响因子：
2.4
作者：
KHOURY, F;HENSHER, R
通讯作者：
HENSHER, R
DOI：
10.1111/j.1708-8208.2009.00212.x
发表时间：
2009-10-01
影响因子：
3.6
作者：
Felice, Pietro;Pistilli, Roberto;Marchetti, Claudio
通讯作者：
Marchetti, Claudio
影响因子：
1.5
作者：
TAYLOR, GI
通讯作者：
TAYLOR, GI
DOI：
--
发表时间：
1986
期刊：
Die Quintessenz
影响因子：
--
作者：
G. Nentwig
通讯作者：
G. Nentwig
DOI：
--
发表时间：
1969
期刊：
Ortopediia travmatologiia i protezirovanie
影响因子：
--
作者：
G. Ilizarov;A. A. Deviatov
通讯作者：
A. A. Deviatov