Increased maternal plasma leptin in early pregnancy and risk of gestational diabetes mellitus
Increased maternal plasma leptin in early pregnancy and risk of gestational diabetes mellitus
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DOI：
10.1097/01.aog.0000113621.53602.7a
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发表时间：
2004-03-01
影响因子：
7.2
通讯作者：
Luthy, DA
中科院分区：
文献类型：
--
作者：
Qiu, CF;Williams, MA;Luthy, DA
目的：新出现的证据表明，瘦素，脂肪细胞衍生的激素，可能有独立的直接影响胰岛素的分泌和行动，除了其对食欲和能量消耗的影响。一些，但不是全部，以前发表的研究表明，母体瘦素浓度可能会增加妊娠合并妊娠糖尿病（GDM）。我们研究了血浆瘦素浓度与GDM风险之间的关系。方法：妇女在妊娠16周前被招募，并随访至分娩。采用免疫分析法测定孕13周孕妇血浆瘦素浓度。我们使用广义线性模型来估计相对危险度和95%的置信区间。结果：GDM发生率为5.7%（47/823）。瘦素浓度升高与GDM风险呈正相关（P
OBJECTIVE: Emerging evidence suggests that leptin, an adipocyte-derived hormone, may have independent direct effects on both insulin secretion and action, in addition to its well documented effects on appetite and energy expenditure. Some, but not all, previously published studies suggest that maternal leptin concentrations may be increased in pregnancies complicated by gestational diabetes mellitus (GDM). We examined the association between plasma leptin concentration and GDM risk.METHODS: Women were recruited before 16 weeks of gestation and were followed up until delivery. Maternal plasma leptin concentrations (collected at 13 weeks of gestation) were measured by using immunoassay. We used generalized linear models to estimate relative risks and 95% confidence intervals.RESULTS: GDM developed in 5.7% of the cohort (47 of 823). Elevated leptin concentrations were positively associated with GDM risk (P for trend