Time-resolved methods in biophysics.: 7.: Photon counting vs. analog time-resolved singlet oxygen phosphorescence detection
Time-resolved methods in biophysics.: 7.: Photon counting vs. analog time-resolved singlet oxygen phosphorescence detection
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DOI：
10.1039/b804333g
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发表时间：
2008-09-01
影响因子：
3.1
通讯作者：
Nonell, Santi
中科院分区：
文献类型：
--
作者：
Jimenez-Banzo, Ana;Ragas, Xavier;Nonell, Santi
光电子学的两个最新进展，即新型近红外敏感光电倍增管和以kHz重复率工作的廉价而强大的二极管泵浦固体激光器，使在光子计数模式下对单线态氧(O-2（a(1)Delta(g))）磷光的时间分辨检测成为可能，从而提高了这种成熟的检测技术的时间分辨、灵敏度和动态范围。从这个角度提供了这种新方法的基本原理和选定的应用示例，这些示例说明了优于传统模拟检测模式的优点。
Two recent advances in optoelectronics, namely novel near-IR sensitive photomultipliers and inexpensive yet powerful diode-pumped solid-state lasers working at kHz repetition rate, enable the time-resolved detection of singlet oxygen (O-2(a(1)Delta(g))) phosphorescence in photon counting mode, thereby boosting the time-resolution, sensitivity, and dynamic range of this well-established detection technique. Principles underlying this novel approach and selected examples of applications are provided in this perspective, which illustrate the advantages over the conventional analog detection mode.